Detailed information of TA system TA242511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3211491..3212125
• Replicon: chromosome
• Accession: NZ_CP095766
• Organism: Pseudomonas chengduensis strain T1624

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MYO55_RS14775
• Protein ID: WP_003291451.1
• Coordinates: 3211491..3211895 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: L1LS63
• Locus tag: MYO55_RS14780
• Protein ID: WP_003285520.1
• Coordinates: 3211895..3212125 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYO55_RS14750	3206670..3207761	-	1092	WP_247722416.1	inovirus-type Gp2 protein	-
MYO55_RS14755	3207968..3209467	-	1500	WP_247722417.1	YfjI family protein	-
MYO55_RS14760	3209520..3209723	-	204	WP_102082584.1	AlpA family phage regulatory protein	-
MYO55_RS14765	3210044..3210376	+	333	WP_036992178.1	hypothetical protein	-
MYO55_RS14770	3210436..3211404	+	969	WP_247722418.1	DUF932 domain-containing protein	-
MYO55_RS14775	3211491..3211895	-	405	WP_003291451.1	tRNA(fMet)-specific endonuclease VapC	Toxin
MYO55_RS14780	3211895..3212125	-	231	WP_003285520.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MYO55_RS14785	3212282..3213286	+	1005	WP_247722419.1	YqaJ viral recombinase family protein	-
MYO55_RS14790	3213378..3214289	+	912	WP_213150151.1	hydrolase or metal-binding protein	-
MYO55_RS14795	3214300..3214797	+	498	WP_213149994.1	DNA repair protein RadC	-
MYO55_RS14800	3214807..3214980	+	174	WP_213149993.1	hypothetical protein	-
MYO55_RS14805	3215392..3215844	+	453	WP_247722420.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3193074..3215844	22770

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-35)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14968.21 Da
• Isoelectric Point: 7.2774

>T242511 WP_003291451.1 NZ_CP095766:c3211895-3211491 [Pseudomonas chengduensis]
MLKYMLDTNMCIFTIKNRPEQVREAFKRHSGQLSISTVTLMELIYGAEKSANPERNLADVEGFAARLEVLPYDAQAAAHS
GQLRAELARIGKPIGPYDQMIAGHARAQGLILVTNNLREFERVPGLRVEDWVSA

Nucleotide

• Length: 405 bp

>T242511 NZ_OW706512:2189804-2190331 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACAAAAACCTACGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8432.41 Da
• Isoelectric Point: 4.2683

>AT242511 WP_003285520.1 NZ_CP095766:c3212125-3211895 [Pseudomonas chengduensis]
MEQGAVFQSNRSQAVRLPKAVALPEDVKRVDVVVVGRARIITPAGEAWDVWFDGEGVTADYMADREQPADQERDAF

Nucleotide

• Length: 231 bp

>AT242511 NZ_OW706512:2189517-2189807 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGATTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: L1LS63