Detailed information of TA system TA024251

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 135219..135769
• Replicon: plasmid pAPA01-011
• Accession: NC_013210
• Organism: Acetobacter pasteurianus IFO 3283-01

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7JII7
• Locus tag: APA01_RS14295
• Protein ID: WP_003618711.1
• Coordinates: 135476..135769 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5QDQ9
• Locus tag: APA01_RS14290
• Protein ID: WP_003618686.1
• Coordinates: 135219..135479 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APA01_RS14260	131486..132067	+	582	WP_012813194.1	group III truncated hemoglobin	-
APA01_RS14265	132095..132394	+	300	WP_012813195.1	DUF1971 domain-containing protein	-
APA01_RS14270	132533..133366	-	834	Protein_122	IS5 family transposase	-
APA01_RS14285	134643..135005	+	363	WP_012813198.1	hypothetical protein	-
APA01_RS14290	135219..135479	+	261	WP_003618686.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
APA01_RS14295	135476..135769	+	294	WP_003618711.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
APA01_RS14300	135971..136954	-	984	WP_012813200.1	Abi family protein	-
APA01_RS14305	137212..139011	-	1800	WP_012813201.1	oleate hydratase	-
APA01_RS14310	139057..139644	-	588	Protein_129	DUF1275 domain-containing protein	-
APA01_RS14315	139630..139875	+	246	Protein_130	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..191799	191799

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 12579.08 Da
• Isoelectric Point: 12.7867

>T24251 WP_003618711.1 NC_013210:135476-135769 [Acetobacter pasteurianus IFO 3283-01]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 294 bp

>T24251 NC_013210:135476-135769 [Acetobacter pasteurianus IFO 3283-01]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 11169.16 Da
• Isoelectric Point: 12.7344

>AT24251 WP_003618686.1 NC_013210:135219-135479 [Acetobacter pasteurianus IFO 3283-01]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKK

Nucleotide

• Length: 261 bp

>AT24251 NC_013210:135219-135479 [Acetobacter pasteurianus IFO 3283-01]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: A0A6N3T9M6