Detailed information of TA system TA242509

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2715753..2717348
• Replicon: chromosome
• Accession: NZ_CP095766
• Organism: Pseudomonas chengduensis strain T1624

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MYO55_RS12445
• Protein ID: WP_247723542.1
• Coordinates: 2716023..2717348 (-)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A1G5YAZ4
• Locus tag: MYO55_RS12440
• Protein ID: WP_017676963.1
• Coordinates: 2715753..2716022 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYO55_RS12435	2714248..2715312	+	1065	WP_247723541.1	type VI secretion system protein TssA	-
MYO55_RS12440	2715753..2716022	-	270	WP_017676963.1	helix-turn-helix domain-containing protein	Antitoxin
MYO55_RS12445	2716023..2717348	-	1326	WP_247723542.1	HipA domain-containing protein	Toxin
MYO55_RS12450	2717601..2717807	+	207	WP_017676961.1	hypothetical protein	-
MYO55_RS12455	2717916..2719058	+	1143	WP_247723543.1	elongation factor P maturation arginine rhamnosyltransferase EarP	-
MYO55_RS12460	2719093..2719665	+	573	WP_003460252.1	elongation factor P	-
MYO55_RS12465	2719765..2720727	-	963	WP_039964599.1	LysR family transcriptional regulator	-
MYO55_RS12470	2720828..2721595	+	768	WP_247723544.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	adeG	2614230..2894702	280472

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-382)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-69)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 49115.50 Da
• Isoelectric Point: 5.8080

>T242509 WP_247723542.1 NZ_CP095766:c2717348-2716023 [Pseudomonas chengduensis]
MHSLTLQLYSGHAWHDAMHLNFEQPEAGLAGACSFGYEQAYLLETLEHIGSRLEHAVSVTVPLDWESYRASEAPAFLHDI
LPAGAARRFLLQRLGDQKPESLGLDLFLLSRCAPAPVGNLRIKEAAAALQESPLLGFSREDVINRDSRFLEYAYEQGAAI
GGATGAGGEAPKLLLTEDREGALHPDAALPDESATRHWFVKFARNQARQTDQDILRSEFCYYRAIQRLGLDTVPAEGLAL
EEGRKPSLWMHRFDRHLSAAGVERSAMESLYSLAGVTVPGSYLLHTDVLHHLVRLWQKTGQGAQVGDMIFEYLQRDLLNQ
ILGNSDNHGRNTSILRNSTGLKLAPIYDLAPMVMDDEGVTRTTKWPQSIEIAGEVNWRQACAALAQWTDADVLYERLRGA
AQDFLALPDLLSDQGLPNSTMNHPRIALRTLHQRLNRWELV

Nucleotide

• Length: 1326 bp

>T242509 NZ_OW706512:398542-398644 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10104.75 Da
• Isoelectric Point: 10.7429

>AT242509 WP_017676963.1 NZ_CP095766:c2716022-2715753 [Pseudomonas chengduensis]
MDIIERNRILTEIQTQLASGELTIGQAVRKLRKEITGLQQARFAQMCKLSLRALRQLEHDESNPTVQTLNSVFNPFGMQV
GIVPKSRIQ

Nucleotide

• Length: 270 bp

>AT242509 NZ_OW706512:c398646-398503 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Structures

Antitoxin

• AlphaFold DB: A0A1G5YAZ4