Detailed information of TA system TA242508

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 937600..938141
• Replicon: chromosome
• Accession: NZ_CP095766
• Organism: Pseudomonas chengduensis strain T1624

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MYO55_RS04165
• Protein ID: WP_125874271.1
• Coordinates: 937600..937896 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A379JUV6
• Locus tag: MYO55_RS04170
• Protein ID: WP_074856106.1
• Coordinates: 937884..938141 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYO55_RS04155	934885..936277	+	1393	Protein_826	TldD/PmbA family protein	-
MYO55_RS04160	936277..937596	+	1320	Protein_827	metallopeptidase TldD-related protein	-
MYO55_RS04165	937600..937896	-	297	WP_125874271.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MYO55_RS04170	937884..938141	-	258	WP_074856106.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MYO55_RS04175	938211..939335	-	1125	WP_247723107.1	class I SAM-dependent methyltransferase	-
MYO55_RS04180	939579..940355	+	777	WP_045734041.1	ferredoxin--NADP reductase	-
MYO55_RS04185	940356..941381	-	1026	WP_247723108.1	hemolysin family protein	-
MYO55_RS04190	941621..941869	+	249	WP_004425048.1	YdcH family protein	-
MYO55_RS04195	941938..942216	+	279	WP_247723109.1	DUF465 domain-containing protein	-
MYO55_RS04200	942478..942954	-	477	WP_247723110.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11464.25 Da
• Isoelectric Point: 6.0752

>T242508 WP_125874271.1 NZ_CP095766:c937896-937600 [Pseudomonas chengduensis]
MAEIVWTNTALEQLDDLAHYIALDKPDATRTLVRRAVETVSRLADFPLSGRVPDELPHSVYREIVVPPCRIFYRYTDTTV
FIIHIMREERVLRAHMLE

Nucleotide

• Length: 297 bp

>T242508 NZ_OW704627:4542785-4543003 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9800.29 Da
• Isoelectric Point: 7.3183

>AT242508 WP_074856106.1 NZ_CP095766:c938141-937884 [Pseudomonas chengduensis]
MKVELVTNLKRQATKILADLHESKEPVLITEHGMPSAYLVDVDDYQFMQRRLALLDALARGERAVIEGNTQNHEQAKERL
SKWLK

Nucleotide

• Length: 258 bp

>AT242508 NZ_OW704627:4542383-4542757 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A379JUV6