Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3995043..3996614 Replicon chromosome
Accession NZ_CP095765
Organism Proteus mirabilis strain T1010

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MYO54_RS18510 Protein ID WP_063073818.1
Coordinates 3995043..3996356 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MYO54_RS18515 Protein ID WP_049203075.1
Coordinates 3996357..3996614 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYO54_RS18490 3990212..3991015 + 804 WP_063073815.1 energy transducer TonB -
MYO54_RS18495 3991069..3992925 - 1857 WP_226694093.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
MYO54_RS18500 3993062..3993991 - 930 WP_004246518.1 metallophosphoesterase -
MYO54_RS18505 3994176..3994640 - 465 WP_063073817.1 DUF1097 domain-containing protein -
MYO54_RS18510 3995043..3996356 - 1314 WP_063073818.1 type II toxin-antitoxin system HipA family toxin Toxin
MYO54_RS18515 3996357..3996614 - 258 WP_049203075.1 helix-turn-helix domain-containing protein Antitoxin
MYO54_RS18520 3996763..3998127 - 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
MYO54_RS18525 3998265..3999905 - 1641 WP_004246512.1 membrane protein insertase YidC -
MYO54_RS18530 3999908..4000168 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
MYO54_RS18535 4000132..4000491 - 360 WP_004246510.1 ribonuclease P protein component -
MYO54_RS18540 4000509..4000652 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49674.86 Da        Isoelectric Point: 6.7643

>T242507 WP_063073818.1 NZ_CP095765:c3996356-3995043 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLVAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKKYTDFRISIAGAQEKTA
LLLKDNDWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

>T242507 NZ_OW704627:3190155-3190257 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT242507 WP_049203075.1 NZ_CP095765:c3996614-3996357 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFEINPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp

>AT242507 NZ_OW704627:c3190259-3190116 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References