Detailed information of TA system TA242506

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3706618..3707317
• Replicon: chromosome
• Accession: NZ_CP095765
• Organism: Proteus mirabilis strain T1010

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MYO54_RS17155
• Protein ID: WP_017628658.1
• Coordinates: 3706618..3707004 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: MYO54_RS17160
• Protein ID: WP_004246828.1
• Coordinates: 3706997..3707317 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYO54_RS17140	3702637..3703218	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
MYO54_RS17145	3703469..3704374	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
MYO54_RS17150	3704384..3706456	+	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
MYO54_RS17155	3706618..3707004	+	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MYO54_RS17160	3706997..3707317	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
MYO54_RS17165	3707366..3707800	-	435	WP_004246827.1	hypothetical protein	-
MYO54_RS17170	3707793..3708677	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
MYO54_RS17175	3708892..3710178	-	1287	WP_063073863.1	DUF3748 domain-containing protein	-
MYO54_RS17180	3710315..3710932	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
MYO54_RS17185	3711233..3711856	+	624	WP_004246821.1	guanylate kinase	-
MYO54_RS17190	3711911..3712186	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T242506 WP_017628658.1 NZ_CP095765:3706618-3707004 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T242506 NZ_OW704627:2039737-2040024 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT242506 WP_004246828.1 NZ_CP095765:3706997-3707317 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT242506 NZ_OW704627:2040011-2040313 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Structures

Antitoxin

• AlphaFold DB: B4EZ97