Detailed information of TA system TA242502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1762642..1763441
• Replicon: chromosome
• Accession: NZ_CP095765
• Organism: Proteus mirabilis strain T1010

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E3RD10
• Locus tag: MYO54_RS08420
• Protein ID: WP_004247966.1
• Coordinates: 1762917..1763441 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: B4EVS2
• Locus tag: MYO54_RS08415
• Protein ID: WP_004247964.1
• Coordinates: 1762642..1762920 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYO54_RS08390	1757992..1759074	+	1083	WP_004242680.1	peptide chain release factor 1	-
MYO54_RS08395	1759074..1759922	+	849	WP_004247962.1	peptide chain release factor N(5)-glutamine methyltransferase	-
MYO54_RS08400	1759900..1760715	+	816	WP_004242688.1	invasion regulator SirB1	-
MYO54_RS08405	1760773..1761627	+	855	WP_004242689.1	3-deoxy-8-phosphooctulonate synthase	-
MYO54_RS08410	1761635..1762564	+	930	WP_017628160.1	TIGR01212 family radical SAM protein	-
MYO54_RS08415	1762642..1762920	+	279	WP_004247964.1	DUF1778 domain-containing protein	Antitoxin
MYO54_RS08420	1762917..1763441	+	525	WP_004247966.1	hypothetical protein	Toxin
MYO54_RS08425	1763522..1765222	-	1701	WP_017628159.1	C4-dicarboxylic acid transporter DauA	-
MYO54_RS08435	1766186..1767127	+	942	WP_004242695.1	glyoxylate/hydroxypyruvate reductase GhrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (5-87)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19192.12 Da
• Isoelectric Point: 9.3561

>T242502 WP_004247966.1 NZ_CP095765:1762917-1763441 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Nucleotide

• Length: 525 bp

>T242502 NZ_OW704627:1403351-1403725 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAAAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
CAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10252.82 Da
• Isoelectric Point: 5.1369

>AT242502 WP_004247964.1 NZ_CP095765:1762642-1762920 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Nucleotide

• Length: 279 bp

>AT242502 NZ_OW704627:1403109-1403351 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Structures

Antitoxin

• AlphaFold DB: B4EVS2