Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 9630..10231 Replicon chromosome
Accession NZ_CP095765
Organism Proteus mirabilis strain T1010

Toxin (Protein)


Gene name doc Uniprot ID A0A7D6AHD8
Locus tag MYO54_RS00040 Protein ID WP_063073825.1
Coordinates 9630..10013 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7D5W489
Locus tag MYO54_RS00045 Protein ID WP_063073826.1
Coordinates 10010..10231 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYO54_RS00025 6124..7230 - 1107 WP_063073822.1 aspartate-semialdehyde dehydrogenase -
MYO54_RS00030 7730..8293 + 564 WP_063073823.1 rRNA adenine N-6-methyltransferase family protein -
MYO54_RS00035 8569..9468 + 900 WP_063073824.1 N-acetylmuramic acid 6-phosphate etherase -
MYO54_RS00040 9630..10013 - 384 WP_063073825.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MYO54_RS00045 10010..10231 - 222 WP_063073826.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MYO54_RS00050 10476..11339 - 864 WP_063073829.1 YicC/YloC family endoribonuclease -
MYO54_RS00055 11466..12182 + 717 WP_004249946.1 ribonuclease PH -
MYO54_RS00060 12264..12908 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
MYO54_RS00065 13227..13832 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
MYO54_RS00070 13952..14410 - 459 WP_063073830.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14485.56 Da        Isoelectric Point: 8.5126

>T242500 WP_063073825.1 NZ_CP095765:c10013-9630 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVEQLAKHLQNLVEKTN

Download         Length: 384 bp

>T242500 NZ_OW704627:c1096779-1096294 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGACGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8290.25 Da        Isoelectric Point: 5.5667

>AT242500 WP_063073826.1 NZ_CP095765:c10231-10010 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNTKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT242500 NZ_OW704627:c1097054-1096767 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAGTCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6AHD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5W489

References