242496

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5237062..5237687 Replicon chromosome
Accession NZ_CP095762
Organism Klebsiella pneumoniae strain KP5362

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag MYA94_RS25620 Protein ID WP_004187928.1
Coordinates 5237062..5237445 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag MYA94_RS25625 Protein ID WP_004150355.1
Coordinates 5237445..5237687 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYA94_RS25605 (5234428) 5234428..5235330 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
MYA94_RS25610 (5235327) 5235327..5235962 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
MYA94_RS25615 (5235959) 5235959..5236888 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
MYA94_RS25620 (5237062) 5237062..5237445 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
MYA94_RS25625 (5237445) 5237445..5237687 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
MYA94_RS25630 (5237881) 5237881..5238798 + 918 WP_004187929.1 alpha/beta hydrolase -
MYA94_RS25635 (5238812) 5238812..5239753 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
MYA94_RS25640 (5239798) 5239798..5240235 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
MYA94_RS25645 (5240232) 5240232..5241092 - 861 WP_004146232.1 virulence factor BrkB family protein -
MYA94_RS25650 (5241086) 5241086..5241685 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T242496 WP_004187928.1 NZ_CP095762:c5237445-5237062 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

>T242496 NZ_OW704291:c4299892-4299491 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCCTTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGACAG
GACTGGACGCTCTTGCGTCCTCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
AG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT242496 WP_004150355.1 NZ_CP095762:c5237687-5237445 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT242496 NZ_OW704291:c4300139-4299873 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References