Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4750521..4751037 Replicon chromosome
Accession NZ_CP095762
Organism Klebsiella pneumoniae strain KP5362

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag MYA94_RS23305 Protein ID WP_004178374.1
Coordinates 4750521..4750805 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MYA94_RS23310 Protein ID WP_002886901.1
Coordinates 4750795..4751037 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYA94_RS23280 (4746005) 4746005..4746268 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
MYA94_RS23285 (4746398) 4746398..4746571 + 174 WP_019725541.1 hypothetical protein -
MYA94_RS23290 (4746574) 4746574..4747317 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MYA94_RS23295 (4747674) 4747674..4749812 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MYA94_RS23300 (4750053) 4750053..4750517 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MYA94_RS23305 (4750521) 4750521..4750805 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYA94_RS23310 (4750795) 4750795..4751037 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MYA94_RS23315 (4751115) 4751115..4753025 - 1911 WP_031593171.1 PRD domain-containing protein -
MYA94_RS23320 (4753048) 4753048..4754202 - 1155 WP_002886900.1 lactonase family protein -
MYA94_RS23325 (4754269) 4754269..4755009 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T242494 WP_004178374.1 NZ_CP095762:c4750805-4750521 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T242494 NZ_OW704291:4129302-4129829 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACAAAAACCTACGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT242494 WP_002886901.1 NZ_CP095762:c4751037-4750795 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT242494 NZ_OW704291:4129015-4129305 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGATTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References