Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4026283..4026902 Replicon chromosome
Accession NZ_CP095762
Organism Klebsiella pneumoniae strain KP5362

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MYA94_RS19835 Protein ID WP_002892050.1
Coordinates 4026684..4026902 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MYA94_RS19830 Protein ID WP_002892066.1
Coordinates 4026283..4026657 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYA94_RS19820 (4021435) 4021435..4022628 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MYA94_RS19825 (4022651) 4022651..4025797 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MYA94_RS19830 (4026283) 4026283..4026657 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MYA94_RS19835 (4026684) 4026684..4026902 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MYA94_RS19840 (4027065) 4027065..4027631 + 567 WP_002892030.1 maltose O-acetyltransferase -
MYA94_RS19845 (4027603) 4027603..4027743 - 141 WP_004147370.1 hypothetical protein -
MYA94_RS19850 (4027764) 4027764..4028234 + 471 WP_002892026.1 YlaC family protein -
MYA94_RS19855 (4028209) 4028209..4029660 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
MYA94_RS19860 (4029761) 4029761..4030459 + 699 WP_002892021.1 GNAT family protein -
MYA94_RS19865 (4030456) 4030456..4030596 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MYA94_RS19870 (4030596) 4030596..4030859 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T242491 WP_002892050.1 NZ_CP095762:4026684-4026902 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T242491 NZ_OW704291:c3549553-3549269 [Salmonella enterica subsp. enterica serovar Typhi]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT242491 WP_002892066.1 NZ_CP095762:4026283-4026657 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT242491 NZ_OW704291:c3549785-3549543 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References