Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2656933..2658521 Replicon chromosome
Accession NZ_CP095762
Organism Klebsiella pneumoniae strain KP5362

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag MYA94_RS13100 Protein ID WP_004190166.1
Coordinates 2656933..2658255 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag MYA94_RS13105 Protein ID WP_002904790.1
Coordinates 2658255..2658521 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYA94_RS13085 (2651989) 2651989..2654490 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
MYA94_RS13090 (2654478) 2654478..2655482 + 1005 WP_004190163.1 fimbrial protein -
MYA94_RS13095 (2655624) 2655624..2656916 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
MYA94_RS13100 (2656933) 2656933..2658255 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
MYA94_RS13105 (2658255) 2658255..2658521 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MYA94_RS13110 (2658786) 2658786..2659112 - 327 WP_004143476.1 hydroxyisourate hydrolase -
MYA94_RS13115 (2659109) 2659109..2659609 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
MYA94_RS13120 (2659587) 2659587..2660966 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
MYA94_RS13125 (2661311) 2661311..2662465 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
MYA94_RS13130 (2662446) 2662446..2663369 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T242489 WP_004190166.1 NZ_CP095762:c2658255-2656933 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T242489 NZ_OW704291:c2303093-2302991 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT242489 WP_002904790.1 NZ_CP095762:c2658521-2658255 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT242489 NZ_OW704291:2302989-2303132 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References