Detailed information of TA system TA024248

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 2301408..2301904
• Replicon: chromosome
• Accession: NC_013204
• Organism: Eggerthella lenta DSM 2243

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C8WII7
• Locus tag: ELEN_RS09835
• Protein ID: WP_015760869.1
• Coordinates: 2301635..2301904 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C8WII6
• Locus tag: ELEN_RS09830
• Protein ID: WP_015760868.1
• Coordinates: 2301408..2301638 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELEN_RS09820	2296626..2298122	-	1497	WP_015760864.1	L,D-transpeptidase/peptidoglycan binding protein	-
ELEN_RS09825	2299074..2299295	-	222	WP_015760865.1	helix-turn-helix transcriptional regulator	-
ELEN_RS16180	2299356..2300342	+	987	WP_015760866.1	hypothetical protein	-
ELEN_RS16185	2300369..2301100	-	732	WP_143924743.1	hypothetical protein	-
ELEN_RS09830	2301408..2301638	+	231	WP_015760868.1	DNA-binding domain-containing protein	Antitoxin
ELEN_RS09835	2301635..2301904	+	270	WP_015760869.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ELEN_RS09840	2301994..2302806	-	813	WP_009304172.1	hypothetical protein	-
ELEN_RS09845	2302869..2303336	-	468	WP_009304171.1	SsrA-binding protein SmpB	-
ELEN_RS09850	2303345..2304496	-	1152	WP_009304170.1	M42 family metallopeptidase	-
ELEN_RS09855	2304666..2304947	-	282	WP_009304169.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (4-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10377.90 Da
• Isoelectric Point: 9.8844

>T24248 WP_015760869.1 NC_013204:2301635-2301904 [Eggerthella lenta DSM 2243]
MSWALAYSERARRQLRKMDPGQRAIVLSWMDKNIDGCDDPRAHGKGLTANRSGQWRYRIGDYRVLCDIVDEKLTVLAIEI
GHRSKIYER

Nucleotide

• Length: 270 bp

>T24248 NC_013204:2301635-2301904 [Eggerthella lenta DSM 2243]
ATGAGCTGGGCGCTCGCGTACTCCGAAAGGGCGAGACGCCAACTGCGCAAGATGGATCCAGGCCAGCGTGCCATCGTCTT
ATCCTGGATGGACAAGAACATCGACGGCTGCGACGATCCGCGCGCACATGGCAAGGGTTTGACGGCAAACCGTTCCGGCC
AATGGCGCTATCGCATAGGCGACTATCGGGTGCTCTGCGATATCGTCGACGAAAAACTGACCGTGCTCGCTATCGAGATC
GGACACCGCAGCAAGATATACGAACGGTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8729.74 Da
• Isoelectric Point: 4.3313

>AT24248 WP_015760868.1 NC_013204:2301408-2301638 [Eggerthella lenta DSM 2243]
MPSSTMTIRLDQNEKNLIADYAQAFGTSVSEFMRKAALERIEDDIDLKTWYAAKAEFDENPVAHSNDEVMREFGLR

Nucleotide

• Length: 231 bp

>AT24248 NC_013204:2301408-2301638 [Eggerthella lenta DSM 2243]
ATGCCCAGCTCGACGATGACTATACGGCTCGACCAGAACGAGAAAAACCTCATAGCCGACTACGCTCAGGCCTTCGGCAC
GTCGGTATCCGAATTCATGCGGAAAGCAGCGCTCGAACGCATCGAGGACGACATCGACCTGAAAACGTGGTACGCCGCTA
AAGCGGAATTCGACGAGAATCCCGTCGCCCACTCCAACGACGAAGTCATGCGCGAGTTCGGATTACGATGA

Structures

Toxin

• AlphaFold DB: C8WII7

Antitoxin

• AlphaFold DB: C8WII6