Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1937112..1937606 Replicon chromosome
Accession NC_013204
Organism Eggerthella lenta DSM 2243

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ELEN_RS08180 Protein ID WP_035585267.1
Coordinates 1937334..1937606 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ELEN_RS08175 Protein ID WP_114513535.1
Coordinates 1937112..1937333 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELEN_RS08150 1932465..1932752 - 288 WP_009307039.1 30S ribosomal protein S15 -
ELEN_RS08155 1933035..1934189 - 1155 WP_015760680.1 HAMP domain-containing histidine kinase -
ELEN_RS08160 1934202..1934900 - 699 WP_015760681.1 response regulator transcription factor -
ELEN_RS08165 1935165..1935842 + 678 WP_015760682.1 leucine-rich repeat domain-containing protein -
ELEN_RS15745 1935868..1936971 + 1104 WP_015760683.1 Exonuclease RNase T and DNA polymerase III -
ELEN_RS08175 1937112..1937333 + 222 WP_114513535.1 antitoxin Antitoxin
ELEN_RS08180 1937334..1937606 + 273 WP_035585267.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ELEN_RS08185 1937876..1938658 + 783 WP_015760686.1 C39 family peptidase -
ELEN_RS08190 1938643..1938894 - 252 WP_009307046.1 TIGR03905 family TSCPD domain-containing protein -
ELEN_RS08195 1938933..1939703 - 771 WP_015760687.1 DNA repair protein RecO -
ELEN_RS08200 1939709..1941214 - 1506 WP_015760688.1 PASTA domain-containing protein -
ELEN_RS08205 1941410..1942333 - 924 WP_009608610.1 GTPase Era -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-67)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10150.78 Da        Isoelectric Point: 10.2288

>T24247 WP_035585267.1 NC_013204:1937334-1937606 [Eggerthella lenta DSM 2243]
MGYSVELTSGAAKQLQSLDRKTLLLVSELIERLDGCENPCMLPNAKKLQGVKNGWRWRSGTYRVLGTVDGSRITIEVFKI
GHRRDVYRGL

Download         Length: 273 bp

>T24247 NC_013204:1937334-1937606 [Eggerthella lenta DSM 2243]
TTGGGCTATTCGGTAGAGTTGACGAGCGGAGCGGCGAAGCAGCTGCAAAGCCTCGATCGCAAAACCCTTCTGCTGGTATC
GGAACTGATCGAGCGCCTTGACGGATGCGAGAACCCCTGCATGCTCCCCAACGCGAAGAAGCTCCAAGGGGTGAAGAACG
GTTGGCGCTGGCGTTCCGGAACGTATCGTGTTCTCGGCACAGTCGACGGTAGCCGGATAACGATCGAGGTATTCAAGATC
GGACATCGTCGAGACGTATACCGCGGCTTATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8276.17 Da        Isoelectric Point: 4.1068

>AT24247 WP_114513535.1 NC_013204:1937112-1937333 [Eggerthella lenta DSM 2243]
MTASAIRFEPNEKEWIAAFAEMNGSTFSAQVRQWTLERLEDELDARDLSQAIEEDDGTRISWSKVKSDLGLAI

Download         Length: 222 bp

>AT24247 NC_013204:1937112-1937333 [Eggerthella lenta DSM 2243]
ATGACGGCATCGGCTATTCGGTTCGAGCCGAATGAGAAGGAATGGATTGCAGCGTTTGCCGAGATGAACGGTTCCACGTT
TTCCGCGCAAGTGCGCCAGTGGACGCTCGAACGCCTTGAGGACGAACTTGACGCTCGGGACCTTTCGCAAGCTATCGAAG
AAGACGATGGCACGCGTATTTCCTGGAGCAAGGTCAAGTCCGATCTCGGTCTGGCGATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References