Detailed information of TA system TA024247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1937112..1937606
• Replicon: chromosome
• Accession: NC_013204
• Organism: Eggerthella lenta DSM 2243

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ELEN_RS08180
• Protein ID: WP_035585267.1
• Coordinates: 1937334..1937606 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ELEN_RS08175
• Protein ID: WP_114513535.1
• Coordinates: 1937112..1937333 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELEN_RS08150	1932465..1932752	-	288	WP_009307039.1	30S ribosomal protein S15	-
ELEN_RS08155	1933035..1934189	-	1155	WP_015760680.1	HAMP domain-containing histidine kinase	-
ELEN_RS08160	1934202..1934900	-	699	WP_015760681.1	response regulator transcription factor	-
ELEN_RS08165	1935165..1935842	+	678	WP_015760682.1	leucine-rich repeat domain-containing protein	-
ELEN_RS15745	1935868..1936971	+	1104	WP_015760683.1	Exonuclease RNase T and DNA polymerase III	-
ELEN_RS08175	1937112..1937333	+	222	WP_114513535.1	antitoxin	Antitoxin
ELEN_RS08180	1937334..1937606	+	273	WP_035585267.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ELEN_RS08185	1937876..1938658	+	783	WP_015760686.1	C39 family peptidase	-
ELEN_RS08190	1938643..1938894	-	252	WP_009307046.1	TIGR03905 family TSCPD domain-containing protein	-
ELEN_RS08195	1938933..1939703	-	771	WP_015760687.1	DNA repair protein RecO	-
ELEN_RS08200	1939709..1941214	-	1506	WP_015760688.1	PASTA domain-containing protein	-
ELEN_RS08205	1941410..1942333	-	924	WP_009608610.1	GTPase Era	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10150.78 Da
• Isoelectric Point: 10.2288

>T24247 WP_035585267.1 NC_013204:1937334-1937606 [Eggerthella lenta DSM 2243]
MGYSVELTSGAAKQLQSLDRKTLLLVSELIERLDGCENPCMLPNAKKLQGVKNGWRWRSGTYRVLGTVDGSRITIEVFKI
GHRRDVYRGL

Nucleotide

• Length: 273 bp

>T24247 NC_013204:1937334-1937606 [Eggerthella lenta DSM 2243]
TTGGGCTATTCGGTAGAGTTGACGAGCGGAGCGGCGAAGCAGCTGCAAAGCCTCGATCGCAAAACCCTTCTGCTGGTATC
GGAACTGATCGAGCGCCTTGACGGATGCGAGAACCCCTGCATGCTCCCCAACGCGAAGAAGCTCCAAGGGGTGAAGAACG
GTTGGCGCTGGCGTTCCGGAACGTATCGTGTTCTCGGCACAGTCGACGGTAGCCGGATAACGATCGAGGTATTCAAGATC
GGACATCGTCGAGACGTATACCGCGGCTTATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8276.17 Da
• Isoelectric Point: 4.1068

>AT24247 WP_114513535.1 NC_013204:1937112-1937333 [Eggerthella lenta DSM 2243]
MTASAIRFEPNEKEWIAAFAEMNGSTFSAQVRQWTLERLEDELDARDLSQAIEEDDGTRISWSKVKSDLGLAI

Nucleotide

• Length: 222 bp

>AT24247 NC_013204:1937112-1937333 [Eggerthella lenta DSM 2243]
ATGACGGCATCGGCTATTCGGTTCGAGCCGAATGAGAAGGAATGGATTGCAGCGTTTGCCGAGATGAACGGTTCCACGTT
TTCCGCGCAAGTGCGCCAGTGGACGCTCGAACGCCTTGAGGACGAACTTGACGCTCGGGACCTTTCGCAAGCTATCGAAG
AAGACGATGGCACGCGTATTTCCTGGAGCAAGGTCAAGTCCGATCTCGGTCTGGCGATTTGA