Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 488461..489098 | Replicon | chromosome |
| Accession | NZ_CP095760 | ||
| Organism | Bacillus velezensis strain ZK-3 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | MXH98_RS02510 | Protein ID | WP_003156187.1 |
| Coordinates | 488748..489098 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | I2HMS5 |
| Locus tag | MXH98_RS02505 | Protein ID | WP_003156188.1 |
| Coordinates | 488461..488742 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MXH98_RS02485 (MXH98_02485) | 484826..485425 | - | 600 | WP_003156193.1 | rhomboid family intramembrane serine protease | - |
| MXH98_RS02490 (MXH98_02490) | 485518..485883 | + | 366 | WP_012116869.1 | holo-ACP synthase | - |
| MXH98_RS02495 (MXH98_02495) | 486048..487055 | + | 1008 | WP_007410230.1 | outer membrane lipoprotein carrier protein LolA | - |
| MXH98_RS02500 (MXH98_02500) | 487172..488341 | + | 1170 | WP_012116870.1 | alanine racemase | - |
| MXH98_RS02505 (MXH98_02505) | 488461..488742 | + | 282 | WP_003156188.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| MXH98_RS02510 (MXH98_02510) | 488748..489098 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| MXH98_RS02515 (MXH98_02515) | 489216..490037 | + | 822 | WP_003156182.1 | STAS domain-containing protein | - |
| MXH98_RS02520 (MXH98_02520) | 490042..490407 | + | 366 | WP_003156180.1 | RsbT antagonist protein RsbS | - |
| MXH98_RS02525 (MXH98_02525) | 490410..490811 | + | 402 | WP_003156178.1 | anti-sigma regulatory factor | - |
| MXH98_RS02530 (MXH98_02530) | 490823..491830 | + | 1008 | WP_007410233.1 | PP2C family protein-serine/threonine phosphatase | - |
| MXH98_RS02535 (MXH98_02535) | 491894..492223 | + | 330 | WP_003156176.1 | anti-sigma factor antagonist RsbV | - |
| MXH98_RS02540 (MXH98_02540) | 492220..492702 | + | 483 | WP_007609591.1 | anti-sigma B factor RsbW | - |
| MXH98_RS02545 (MXH98_02545) | 492668..493456 | + | 789 | WP_003156171.1 | RNA polymerase sigma factor SigB | - |
| MXH98_RS02550 (MXH98_02550) | 493456..494058 | + | 603 | WP_012116871.1 | PP2C family serine/threonine-protein phosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T242463 WP_003156187.1 NZ_CP095760:488748-489098 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T242463 NZ_OW443151:368249-368503 [Vibrio cholerae]
ATGAGAATCGTTTCTTTTACAGAAGCTAGGAATAGTTTAAAAGCAGTCTTGGATGCCGTTGTGAATGATGCGGATACAAC
CGTCATCACTCGACGTGATTCAGAAGATGCCGTGGTTATGTCGCTGGATTATTACAATAGTCTAATGGAAACCGTACATT
TGCTTCGCTCTCCAGCGAACGCTGAACATCTAAACCGTTCCATTGCCCAGTTCAAAGCGGGAAAAGTTACCCAAAGAGAT
CTGATTGATGAGTAG
ATGAGAATCGTTTCTTTTACAGAAGCTAGGAATAGTTTAAAAGCAGTCTTGGATGCCGTTGTGAATGATGCGGATACAAC
CGTCATCACTCGACGTGATTCAGAAGATGCCGTGGTTATGTCGCTGGATTATTACAATAGTCTAATGGAAACCGTACATT
TGCTTCGCTCTCCAGCGAACGCTGAACATCTAAACCGTTCCATTGCCCAGTTCAAAGCGGGAAAAGTTACCCAAAGAGAT
CTGATTGATGAGTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10562.92 Da Isoelectric Point: 6.4706
>AT242463 WP_003156188.1 NZ_CP095760:488461-488742 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT242463 NZ_OW443151:368496-368759 [Vibrio cholerae]
ATGAGTAGTCGTTTACTGTCATGGACAGATGAGTCCTGGGATGACTACTTGTACTGGCAAACACAAGACAAAAAAACACT
CAAGCGGATCAATAAAATCATCAATGATGTTAAGCGTTCACCGTTTGAAGGCATTGGTAAACCAGAGCCTCTAAAAGAAA
ATCTATCTGGTTTTTGGTCTCGACGGATCGATGATACAAATAGACTGGTTTATGCTGTTGATGATAATGCAATAACGATT
ATTTCGTGTCGCTACCATTATTGA
ATGAGTAGTCGTTTACTGTCATGGACAGATGAGTCCTGGGATGACTACTTGTACTGGCAAACACAAGACAAAAAAACACT
CAAGCGGATCAATAAAATCATCAATGATGTTAAGCGTTCACCGTTTGAAGGCATTGGTAAACCAGAGCCTCTAAAAGAAA
ATCTATCTGGTTTTTGGTCTCGACGGATCGATGATACAAATAGACTGGTTTATGCTGTTGATGATAATGCAATAACGATT
ATTTCGTGTCGCTACCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|