Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3661970..3662495 Replicon chromosome
Accession NZ_CP095749
Organism Streptomyces yunnanensis strain P86

Toxin (Protein)


Gene name relE Uniprot ID A0A1T4SXS3
Locus tag MOV08_RS15835 Protein ID WP_032763468.1
Coordinates 3662232..3662495 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A8EK65
Locus tag MOV08_RS15830 Protein ID WP_039633133.1
Coordinates 3661970..3662239 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV08_RS15815 (MOV08_15815) 3657937..3658686 - 750 WP_039633129.1 GntR family transcriptional regulator -
MOV08_RS15820 (MOV08_15820) 3658905..3659666 + 762 WP_039640898.1 PIG-L family deacetylase -
MOV08_RS15825 (MOV08_15825) 3659872..3661548 - 1677 WP_275307804.1 hypothetical protein -
MOV08_RS15830 (MOV08_15830) 3661970..3662239 + 270 WP_039633133.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOV08_RS15835 (MOV08_15835) 3662232..3662495 + 264 WP_032763468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOV08_RS15840 (MOV08_15840) 3662631..3662837 - 207 WP_275307805.1 hypothetical protein -
MOV08_RS15845 (MOV08_15845) 3663205..3663963 + 759 WP_275307806.1 WXG100 family type VII secretion target -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-59)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10056.49 Da        Isoelectric Point: 8.5041

>T242461 WP_032763468.1 NZ_CP095749:3662232-3662495 [Streptomyces yunnanensis]
VSEYRTVFRPEAQAELRKVPRDMALRILAKLTELESDPLGFNTTALVSQPDRRRLRVGDYRVIYTIDNGELVVWVVHVGH
RSTVYDT

Download         Length: 264 bp

>T242461 NZ_OW443151:356220-356507 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10275.71 Da        Isoelectric Point: 4.6168

>AT242461 WP_039633133.1 NZ_CP095749:3661970-3662239 [Streptomyces yunnanensis]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIDVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARSE

Download         Length: 270 bp

>AT242461 NZ_OW443151:355942-356223 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGTATCATCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1T4SXS3

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8EK65

References