Detailed information of TA system TA242460

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazF-pemI/MazF(toxin)
• Location: 306219..306855
• Replicon: chromosome
• Accession: NZ_CP095743
• Organism: Niallia sp. Man26

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A7V7UTN4
• Locus tag: L8T27_RS01620
• Protein ID: WP_019156408.1
• Coordinates: 306505..306855 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: L8T27_RS01615
• Protein ID: WP_127740842.1
• Coordinates: 306219..306500 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L8T27_RS01590 (L8T27_001590)	301339..302313	+	975	WP_237940582.1	UV DNA damage repair endonuclease UvsE	-
L8T27_RS01595 (L8T27_001595)	302328..303050	-	723	WP_233316919.1	rhomboid family intramembrane serine protease	-
L8T27_RS01600 (L8T27_001600)	303151..303501	+	351	WP_233316920.1	holo-ACP synthase	-
L8T27_RS01605 (L8T27_001605)	303667..304677	+	1011	WP_233316921.1	outer membrane lipoprotein carrier protein LolA	-
L8T27_RS01610 (L8T27_001610)	304827..305981	+	1155	WP_237942205.1	alanine racemase	-
L8T27_RS01615 (L8T27_001615)	306219..306500	+	282	WP_127740842.1	CopG family ribbon-helix-helix protein	Antitoxin
L8T27_RS01620 (L8T27_001620)	306505..306855	+	351	WP_019156408.1	type II toxin-antitoxin system endoribonuclease NdoA	Toxin
L8T27_RS01625 (L8T27_001625)	307128..307949	+	822	WP_233316922.1	STAS domain-containing protein	-
L8T27_RS01630 (L8T27_001630)	307951..308307	+	357	WP_127740846.1	STAS domain-containing protein	-
L8T27_RS01635 (L8T27_001635)	308311..308712	+	402	WP_233316923.1	anti-sigma regulatory factor	-
L8T27_RS01640 (L8T27_001640)	308724..309734	+	1011	WP_233316924.1	PP2C family protein-serine/threonine phosphatase	-
L8T27_RS01645 (L8T27_001645)	309792..310124	+	333	WP_233316925.1	anti-sigma factor antagonist	-
L8T27_RS01650 (L8T27_001650)	310121..310594	+	474	WP_233316926.1	anti-sigma B factor RsbW	-
L8T27_RS01655 (L8T27_001655)	310572..311369	+	798	WP_233316927.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13034.08 Da
• Isoelectric Point: 4.8998

>T242460 WP_019156408.1 NZ_CP095743:306505-306855 [Niallia sp. Man26]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQISLGLIEF

Nucleotide

• Length: 351 bp

>T242460 NZ_OW443151:355126-355413 [Vibrio cholerae]
ATGACATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAGGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10825.41 Da
• Isoelectric Point: 8.4775

>AT242460 WP_127740842.1 NZ_CP095743:306219-306500 [Niallia sp. Man26]
VSESSATTEIMIKLPKHLLSELDGFVKQENVNRSEFIYQATKMYLRERKKRHIRESMRRGYMEMAKLNLSIASESFLAEY
EAEHTVERLVSGG

Nucleotide

• Length: 282 bp

>AT242460 NZ_OW443151:355424-355741 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGCAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGTGTACACAGAAATACGGTGAGTAATTTGATTAATGGCGGAGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAATACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGTAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Structures

Toxin

• AlphaFold DB: A0A7V7UTN4