Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2120856..2121445 Replicon chromosome
Accession NZ_CP095742
Organism Luteibacter aegosomatissinici strain 353

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L2Y97_RS09515 Protein ID WP_247435941.1
Coordinates 2121191..2121445 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L2Y97_RS09510 Protein ID WP_247435938.1
Coordinates 2120856..2121194 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y97_RS09485 (L2Y97_09485) 2116289..2116927 - 639 WP_247435928.1 MarC family protein -
L2Y97_RS09495 (L2Y97_09495) 2117220..2118341 - 1122 WP_247435931.1 ribonuclease D -
L2Y97_RS09500 (L2Y97_09500) 2118448..2120403 + 1956 WP_247435934.1 formylglycine-generating enzyme family protein -
L2Y97_RS09505 (L2Y97_09505) 2120508..2120852 + 345 WP_247435936.1 hypothetical protein -
L2Y97_RS09510 (L2Y97_09510) 2120856..2121194 - 339 WP_247435938.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L2Y97_RS09515 (L2Y97_09515) 2121191..2121445 - 255 WP_247435941.1 type II toxin-antitoxin system HicA family toxin Toxin
L2Y97_RS09520 (L2Y97_09520) 2121593..2122189 + 597 WP_247435944.1 TetR/AcrR family transcriptional regulator -
L2Y97_RS09525 (L2Y97_09525) 2122323..2123036 + 714 WP_247435947.1 SDR family oxidoreductase -
L2Y97_RS09530 (L2Y97_09530) 2123046..2124329 - 1284 WP_247435949.1 PAS domain-containing methyl-accepting chemotaxis protein -
L2Y97_RS09535 (L2Y97_09535) 2124657..2124968 + 312 WP_247435952.1 hypothetical protein -
L2Y97_RS09540 (L2Y97_09540) 2124965..2125366 + 402 WP_247435955.1 Rap1a/Tai family immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(56-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9412.84 Da        Isoelectric Point: 11.3689

>T242458 WP_247435941.1 NZ_CP095742:c2121445-2121191 [Luteibacter aegosomatissinici]
MTSRHQRTLDLIATRPTSGNVKWADIVALLRHLGASLREAEGSRITVLLFGEVRVFHRPHPSPDTDKGAVADIRKWLYRN
GVIA

Download         Length: 255 bp

>T242458 NZ_OW443151:c344754-344476 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAGCAGCCGC
AGAAAAAACGGATGAGCTCATAGAAACCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGGGTTCAGCGTGATGGTA
TTCGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12438.25 Da        Isoelectric Point: 5.6398

>AT242458 WP_247435938.1 NZ_CP095742:c2121194-2120856 [Luteibacter aegosomatissinici]
MNNIMVIDGHRAVVQYDPEIDMFRGEFVGLNGGADFYAPDVEGLRREGVISLRVFMEACREAGIPAVRTFSGKFQARVTA
ELHLRSTEAAAARGISLNQFVQHAMERELLVV

Download         Length: 339 bp

>AT242458 NZ_OW443151:c345035-344751 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGGAC
TCTTAGCGATGCTTGCCGTGAACTCACCGAACAATTAGCTGAACAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCGGTATTCGTTGAACATGACATCGCCAAAGTGCGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGTCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References