Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 422907..423493 Replicon chromosome
Accession NZ_CP095732
Organism Abyssibius alkaniclasticus strain 960558

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LGT41_RS02275 Protein ID WP_274128406.1
Coordinates 423137..423493 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LGT41_RS02270 Protein ID WP_274128405.1
Coordinates 422907..423143 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGT41_RS02240 (LGT41_0002235) 418137..418592 + 456 WP_274128400.1 Lrp/AsnC family transcriptional regulator -
LGT41_RS02250 (LGT41_0002245) 418878..419747 - 870 WP_274128401.1 hypothetical protein -
LGT41_RS02255 (LGT41_0002250) 419854..420720 - 867 WP_274128402.1 LysR family transcriptional regulator -
LGT41_RS02260 (LGT41_0002255) 420822..421430 + 609 WP_274128403.1 ribonuclease HII -
LGT41_RS02265 (LGT41_0002260) 421500..422612 + 1113 WP_274128404.1 site-specific DNA-methyltransferase -
LGT41_RS02270 (LGT41_0002265) 422907..423143 + 237 WP_274128405.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LGT41_RS02275 (LGT41_0002270) 423137..423493 + 357 WP_274128406.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LGT41_RS02280 (LGT41_0002275) 423552..424676 - 1125 WP_274128407.1 alkane 1-monooxygenase -
LGT41_RS02285 (LGT41_0002280) 424733..425758 - 1026 WP_274128408.1 A/G-specific adenine glycosylase -
LGT41_RS02290 (LGT41_0002285) 425840..426361 + 522 WP_274128409.1 DciA family protein -
LGT41_RS02295 (LGT41_0002290) 426358..427026 + 669 WP_274128410.1 DsbA family protein -
LGT41_RS02300 (LGT41_0002295) 427033..428007 - 975 WP_274128411.1 tetraacyldisaccharide 4'-kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-112)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12924.80 Da        Isoelectric Point: 6.9516

>T242435 WP_274128406.1 NZ_CP095732:423137-423493 [Abyssibius alkaniclasticus]
VVSRNSYQPDRGDLVWLDFTPNAGTEQGGRRPALVLSGKDFNIATGLALVCPITTKEKLNSFDVKLPRGAKLSGVVIASQ
VRTLDWIARNVEFNSKADHQTMCEVLGRIEAILEIDLS

Download         Length: 357 bp

>T242435 NZ_OW443148:c395101-394802 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8810.05 Da        Isoelectric Point: 8.6188

>AT242435 WP_274128405.1 NZ_CP095732:422907-423143 [Abyssibius alkaniclasticus]
MQLSISKWGNSLALRLPRHLVREARLAEGAKVTLETRDGSLVVTPVRKKFKLSELLADYNKSESAEVDWGKQEGDEAW

Download         Length: 237 bp

>AT242435 NZ_OW443148:c395340-395098 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References