Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 193401..194030 Replicon chromosome
Accession NZ_CP095726
Organism Listeria innocua strain 2010L-2059

Toxin (Protein)


Gene name pemK Uniprot ID Q92DC7
Locus tag QMF10_RS03305 Protein ID WP_010990666.1
Coordinates 193683..194030 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7U7S1X0
Locus tag QMF10_RS03300 Protein ID WP_003766128.1
Coordinates 193401..193679 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMF10_RS03280 (EWI69_03285) 188698..190182 + 1485 WP_207577334.1 PH domain-containing protein -
QMF10_RS03285 (EWI69_03290) 190333..191712 + 1380 WP_003766122.1 protoporphyrinogen oxidase -
QMF10_RS03290 (EWI69_03295) 191714..192070 + 357 WP_003766124.1 holo-ACP synthase -
QMF10_RS03295 (EWI69_03300) 192089..193195 + 1107 WP_003766126.1 alanine racemase -
QMF10_RS03300 (EWI69_03305) 193401..193679 + 279 WP_003766128.1 CopG family ribbon-helix-helix protein Antitoxin
QMF10_RS03305 (EWI69_03310) 193683..194030 + 348 WP_010990666.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QMF10_RS03310 (EWI69_03315) 194280..195116 + 837 WP_003766130.1 RsbT co-antagonist protein RsbRA -
QMF10_RS03315 (EWI69_03320) 195122..195478 + 357 WP_003721457.1 STAS domain-containing protein -
QMF10_RS03320 (EWI69_03325) 195481..195891 + 411 WP_207577335.1 anti-sigma regulatory factor -
QMF10_RS03325 (EWI69_03330) 195908..196912 + 1005 WP_003761312.1 PP2C family protein-serine/threonine phosphatase -
QMF10_RS03330 (EWI69_03335) 197062..197406 + 345 WP_003721460.1 anti sigma b factor antagonist RsbV -
QMF10_RS03335 (EWI69_03340) 197390..197863 + 474 WP_003761314.1 anti-sigma B factor RsbW -
QMF10_RS03340 (EWI69_03345) 197841..198620 + 780 WP_207577336.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12801.85 Da        Isoelectric Point: 6.4735

>T242431 WP_010990666.1 NZ_CP095726:193683-194030 [Listeria innocua]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNQALEVSLGVVEF

Download         Length: 348 bp

>T242431 NZ_OW443148:c370246-369749 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10575.05 Da        Isoelectric Point: 4.2980

>AT242431 WP_003766128.1 NZ_CP095726:193401-193679 [Listeria innocua]
VLEKEKRTIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp

>AT242431 NZ_OW443148:c370515-370243 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7E4N0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7S1X0

References