Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 484284..484913 Replicon chromosome
Accession NZ_CP095723
Organism Listeria innocua strain 2015L-6714

Toxin (Protein)


Gene name pemK Uniprot ID Q92DC7
Locus tag QMZ19_RS02760 Protein ID WP_010990666.1
Coordinates 484566..484913 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H1GC21
Locus tag QMZ19_RS02755 Protein ID WP_003761302.1
Coordinates 484284..484562 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMZ19_RS02735 (MXK34_02740) 479581..481065 + 1485 WP_247412817.1 PH domain-containing protein -
QMZ19_RS02740 (MXK34_02745) 481216..482595 + 1380 WP_247412824.1 protoporphyrinogen oxidase -
QMZ19_RS02745 (MXK34_02750) 482597..482953 + 357 WP_160465244.1 holo-ACP synthase -
QMZ19_RS02750 (MXK34_02755) 482972..484078 + 1107 WP_185341196.1 alanine racemase -
QMZ19_RS02755 (MXK34_02760) 484284..484562 + 279 WP_003761302.1 CopG family ribbon-helix-helix protein Antitoxin
QMZ19_RS02760 (MXK34_02765) 484566..484913 + 348 WP_010990666.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QMZ19_RS02765 (MXK34_02770) 485165..486001 + 837 WP_003771126.1 STAS domain-containing protein -
QMZ19_RS02770 (MXK34_02775) 486007..486363 + 357 WP_003721457.1 STAS domain-containing protein -
QMZ19_RS02775 (MXK34_02780) 486366..486776 + 411 WP_010990667.1 anti-sigma regulatory factor -
QMZ19_RS02780 (MXK34_02785) 486793..487797 + 1005 WP_160465246.1 PP2C family protein-serine/threonine phosphatase -
QMZ19_RS02785 (MXK34_02790) 487947..488291 + 345 WP_247412826.1 anti sigma b factor antagonist RsbV -
QMZ19_RS02790 (MXK34_02795) 488275..488748 + 474 WP_003761314.1 anti-sigma B factor RsbW -
QMZ19_RS02795 (MXK34_02800) 488726..489505 + 780 WP_010990669.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12801.85 Da        Isoelectric Point: 6.4735

>T242429 WP_010990666.1 NZ_CP095723:484566-484913 [Listeria innocua]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNQALEVSLGVVEF

Download         Length: 348 bp

>T242429 NZ_OW443147:c2425036-2424098 [Vibrio cholerae]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAGTTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGATTTCGAGAGAGATTTTGGTGGGTTTTTTAACCTA
TACATTAAGTCACCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCTCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCCATGATGTTAATTGAACTGCAAAAA
CATTTCACAGAAAGGGATCATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAATTGCAGAACATTAACAAATTGGCAAAGAATCAAGCAAAACACCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10605.13 Da        Isoelectric Point: 4.2980

>AT242429 WP_003761302.1 NZ_CP095723:484284-484562 [Listeria innocua]
VLEKEKRMIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp

>AT242429 NZ_OW443147:c2425820-2425029 [Vibrio cholerae]
ATGTCATCTAAAATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTCCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTGCAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAAAATTGGTTTTACTGCGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTTAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCGTAGATGAAACAAGAATTAAATTGGGGGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7E4N0

Antitoxin

Source ID Structure
AlphaFold DB H1GC21

References