Detailed information of TA system TA242419

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2699975..2701563
• Replicon: chromosome
• Accession: NZ_CP095557
• Organism: Klebsiella pneumoniae strain BA11088

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MXX37_RS13285
• Protein ID: WP_064162061.1
• Coordinates: 2699975..2701297 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: MXX37_RS13290
• Protein ID: WP_002904790.1
• Coordinates: 2701297..2701563 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MXX37_RS13270 (2695031)	2695031..2697532	+	2502	WP_064162059.1	fimbria/pilus outer membrane usher protein	-
MXX37_RS13275 (2697520)	2697520..2698524	+	1005	WP_064162060.1	fimbrial protein	-
MXX37_RS13280 (2698666)	2698666..2699958	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MXX37_RS13285 (2699975)	2699975..2701297	-	1323	WP_064162061.1	type II toxin-antitoxin system HipA family toxin	Toxin
MXX37_RS13290 (2701297)	2701297..2701563	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MXX37_RS13295 (2701829)	2701829..2702155	-	327	WP_064162062.1	hydroxyisourate hydrolase	-
MXX37_RS13300 (2702152)	2702152..2702652	-	501	WP_064162063.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MXX37_RS13305 (2702630)	2702630..2704009	-	1380	WP_040245186.1	nucleobase:cation symporter-2 family protein	-
MXX37_RS13310 (2704355)	2704355..2705509	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
MXX37_RS13315 (2705490)	2705490..2706413	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49155.46 Da
• Isoelectric Point: 7.5357

>T242419 WP_064162061.1 NZ_CP095557:c2701297-2699975 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T242419 NZ_OW052571:c3678996-3678589 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT242419 WP_002904790.1 NZ_CP095557:c2701563-2701297 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT242419 NZ_OW052571:c3679208-3678993 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8