Detailed information of TA system TA242410

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 791712..792369
• Replicon: chromosome
• Accession: NZ_CP095557
• Organism: Klebsiella pneumoniae strain BA11088

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MXX37_RS03945
• Protein ID: WP_040245400.1
• Coordinates: 791959..792369 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: MXX37_RS03940
• Protein ID: WP_002916312.1
• Coordinates: 791712..791978 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MXX37_RS03915 (786868)	786868..788301	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
MXX37_RS03920 (788420)	788420..789148	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
MXX37_RS03925 (789198)	789198..789509	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
MXX37_RS03930 (789673)	789673..790332	+	660	WP_048334397.1	hemolysin III family protein	-
MXX37_RS03935 (790483)	790483..791466	-	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
MXX37_RS03940 (791712)	791712..791978	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
MXX37_RS03945 (791959)	791959..792369	+	411	WP_040245400.1	protein YgfX	Toxin
MXX37_RS03950 (792376)	792376..792897	-	522	WP_002916308.1	flavodoxin FldB	-
MXX37_RS03955 (792998)	792998..793894	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
MXX37_RS03960 (793917)	793917..794630	+	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MXX37_RS03965 (794636)	794636..796369	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T242410 WP_040245400.1 NZ_CP095557:791959-792369 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T242410 NZ_OW052571:3601146-3601583 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT242410 WP_002916312.1 NZ_CP095557:791712-791978 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT242410 NZ_OW052571:3601693-3601938 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41