Detailed information of TA system TA242408

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3429594..3430110
• Replicon: chromosome
• Accession: NZ_CP095556
• Organism: Pseudomonas mosselii strain 923

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MXB02_RS15855
• Protein ID: WP_088851695.1
• Coordinates: 3429594..3429875 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A246GY67
• Locus tag: MXB02_RS15860
• Protein ID: WP_050705246.1
• Coordinates: 3429865..3430110 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MXB02_RS15835 (MXB02_15835)	3424915..3425937	-	1023	WP_247283227.1	histone deacetylase family protein	-
MXB02_RS15840 (MXB02_15840)	3425937..3427178	-	1242	WP_247283229.1	Zn-dependent hydrolase	-
MXB02_RS15845 (MXB02_15845)	3427195..3428499	-	1305	WP_247283230.1	MFS transporter	-
MXB02_RS15850 (MXB02_15850)	3428658..3429575	+	918	WP_062361051.1	LysR family transcriptional regulator	-
MXB02_RS15855 (MXB02_15855)	3429594..3429875	-	282	WP_088851695.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MXB02_RS15860 (MXB02_15860)	3429865..3430110	-	246	WP_050705246.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MXB02_RS15865 (MXB02_15865)	3430175..3430915	-	741	WP_088851694.1	hypothetical protein	-
MXB02_RS15870 (MXB02_15870)	3431068..3431814	-	747	WP_069017253.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3419074..3444695	25621

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10968.82 Da
• Isoelectric Point: 11.0508

>T242408 WP_088851695.1 NZ_CP095556:c3429875-3429594 [Pseudomonas mosselii]
MTYRLEFLPSALKEWEKLGHTVREQARKKLRQRLLSPKVGVDALRDLPNHYKIKLRASGYRLVYRVEDDRVVVVVVAIGK
RERGQAYRSAYTR

Nucleotide

• Length: 282 bp

>T242408 NZ_OW052571:c3515240-3514812 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8885.36 Da
• Isoelectric Point: 4.4000

>AT242408 WP_050705246.1 NZ_CP095556:c3430110-3429865 [Pseudomonas mosselii]
MQNIFADVTVSVSELKKNPTAVMADAQGKPVAVLNHNRVMGYMVPAELYEAMMERLEDIELVALVKARAGEKGIPVELDD
L

Nucleotide

• Length: 246 bp

>AT242408 NZ_OW052571:c3515521-3515264 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A246GY67