Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 675809..676449 Replicon chromosome
Accession NZ_CP095556
Organism Pseudomonas mosselii strain 923

Toxin (Protein)


Gene name vapC Uniprot ID A0A1H9S264
Locus tag MXB02_RS03030 Protein ID WP_028691288.1
Coordinates 675809..676219 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A246GUY5
Locus tag MXB02_RS03035 Protein ID WP_036986184.1
Coordinates 676219..676449 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MXB02_RS03005 (MXB02_03005) 672807..673232 - 426 WP_028691293.1 DUF2946 domain-containing protein -
MXB02_RS03010 (MXB02_03010) 673258..673740 - 483 WP_247283956.1 copper chaperone PCu(A)C -
MXB02_RS03015 (MXB02_03015) 673788..674177 - 390 WP_197866998.1 DUF2946 domain-containing protein -
MXB02_RS03020 (MXB02_03020) 674418..675272 - 855 WP_197866997.1 SPFH domain-containing protein -
MXB02_RS03025 (MXB02_03025) 675299..675736 - 438 WP_247283957.1 NfeD family protein -
MXB02_RS03030 (MXB02_03030) 675809..676219 - 411 WP_028691288.1 tRNA(fMet)-specific endonuclease VapC Toxin
MXB02_RS03035 (MXB02_03035) 676219..676449 - 231 WP_036986184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MXB02_RS03040 (MXB02_03040) 676532..677260 - 729 WP_028691287.1 cobalt-precorrin-6A reductase -
MXB02_RS03045 (MXB02_03045) 677257..678351 - 1095 WP_028691286.1 cobalt-precorrin-5B (C(1))-methyltransferase -
MXB02_RS03050 (MXB02_03050) 678344..679555 - 1212 WP_028691285.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
MXB02_RS03055 (MXB02_03055) 679723..681048 + 1326 WP_247283959.1 precorrin-3B synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15234.59 Da        Isoelectric Point: 9.5447

>T242407 WP_028691288.1 NZ_CP095556:c676219-675809 [Pseudomonas mosselii]
MLRYMLDTNICIFTIKNKPQVVREAFNRHHGQLAISTVTLMELIYGAEKSAAPERNLAIVEGFAARLDVLDYDIQGAAHT
AQLRAELAKAGTPIGPYDRMIAGHARARGLTLVTNNLREFQRVPGLRVEDWVTHPR

Download         Length: 411 bp

>T242407 NZ_OW052571:c3340317-3339883 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8459.36 Da        Isoelectric Point: 4.2821

>AT242407 WP_036986184.1 NZ_CP095556:c676449-676219 [Pseudomonas mosselii]
MEQGAVFKSNRSQAIRMPKALALPEDVTRVDIVAVGRSRIISPAGESWDSWFEGDDVSSDFMASREQPADQEREGF

Download         Length: 231 bp

>AT242407 NZ_OW052571:c3340502-3340323 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H9S264

Antitoxin

Source ID Structure
AlphaFold DB A0A246GUY5

References