Detailed information of TA system TA242406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 4629311..4630266
• Replicon: chromosome
• Accession: NZ_CP095552
• Organism: Gordonia hongkongensis strain JCM 31934

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: MVF96_RS20900
• Protein ID: WP_247450284.1
• Coordinates: 4629311..4629886 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A1C3YXT2
• Locus tag: MVF96_RS20905
• Protein ID: WP_058249717.1
• Coordinates: 4629883..4630266 (-)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MVF96_RS20875 (MVF96_20875)	4625565..4626572	+	1008	WP_078113771.1	LacI family DNA-binding transcriptional regulator	-
MVF96_RS20880 (MVF96_20880)	4626576..4626893	-	318	WP_078113770.1	DUF2470 domain-containing protein	-
MVF96_RS20885 (MVF96_20885)	4626886..4627617	-	732	WP_247450280.1	tyrosine-protein phosphatase	-
MVF96_RS20890 (MVF96_20890)	4627710..4628342	+	633	WP_247452149.1	flavin reductase family protein	-
MVF96_RS20895 (MVF96_20895)	4628367..4629314	-	948	WP_247450282.1	PfkB family carbohydrate kinase	-
MVF96_RS20900 (MVF96_20900)	4629311..4629886	-	576	WP_247450284.1	zeta toxin family protein	Toxin
MVF96_RS20905 (MVF96_20905)	4629883..4630266	-	384	WP_058249717.1	hypothetical protein	Antitoxin
MVF96_RS20910 (MVF96_20910)	4630390..4630938	-	549	WP_068970820.1	peptide-methionine (S)-S-oxide reductase MsrA	-
MVF96_RS20915 (MVF96_20915)	4630935..4631429	-	495	WP_247450285.1	peptide-methionine (R)-S-oxide reductase MsrB	-
MVF96_RS20920 (MVF96_20920)	4631586..4632809	-	1224	WP_247452150.1	acyl-CoA dehydrogenase family protein	-
MVF96_RS20925 (MVF96_20925)	4632888..4633976	-	1089	WP_247450287.1	VOC family protein	-
MVF96_RS20930 (MVF96_20930)	4634223..4635116	+	894	WP_137809479.1	acetaldehyde dehydrogenase (acetylating)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (2-142)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-70)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21202.34 Da
• Isoelectric Point: 10.1705

>T242406 WP_247450284.1 NZ_CP095552:c4629886-4629311 [Gordonia hongkongensis]
VTPRLDLVVGCNGAGKSTLVERHLQPLLHVPFVNADLIARQRWPDSAEAHSYDAARLAAATRDTLIERGTSFIAETVFSH
PSKLELIERAHTAGYRVALHVVMIPEALAVHRVRLRVDSGGHAVPEVKIRERFRRLWPLVRTAIARSDLATVYANERPTT
RIVARYVDGLVAGVPDWPDWTPGALTDTKAR

Nucleotide

• Length: 576 bp

>T242406 NZ_OW052571:c3187499-3186618 [Mycobacterium tuberculosis]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCCATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 13713.16 Da
• Isoelectric Point: 5.2363

>AT242406 WP_058249717.1 NZ_CP095552:c4630266-4629883 [Gordonia hongkongensis]
MSTGTDKVTRLSAALVTDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRQRVEAALAGDLPGEVLTAEEAVVYDAEI
DAHLEARLTTDDHVVRRASAGLSSVVVDDAGRLVEHRPDGTSVILEQ

Nucleotide

• Length: 384 bp

>AT242406 NZ_OW052571:c3188119-3187496 [Mycobacterium tuberculosis]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTACGCGCTCGGCCGAAGCGAGCATCGGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C3YXT2