Detailed information of TA system TA242405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2913107..2913669
• Replicon: chromosome
• Accession: NZ_CP095552
• Organism: Gordonia hongkongensis strain JCM 31934

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MVF96_RS13270
• Protein ID: WP_243829300.1
• Coordinates: 2913107..2913397 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MVF96_RS13275
• Protein ID: WP_247449296.1
• Coordinates: 2913394..2913669 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MVF96_RS13235 (MVF96_13235)	2908232..2908450	-	219	WP_247449291.1	hypothetical protein	-
MVF96_RS13240 (MVF96_13240)	2908673..2908825	-	153	WP_159372047.1	hypothetical protein	-
MVF96_RS13245 (MVF96_13245)	2908815..2909963	-	1149	WP_272499259.1	TetR/AcrR family transcriptional regulator	-
MVF96_RS13250 (MVF96_13250)	2910396..2910842	+	447	WP_247449293.1	hypothetical protein	-
MVF96_RS13255 (MVF96_13255)	2910903..2911564	+	662	Protein_2607	IS21-like element helper ATPase IstB	-
MVF96_RS13260 (MVF96_13260)	2911583..2912882	+	1300	WP_247449294.1	IS3 family transposase	-
MVF96_RS13265 (MVF96_13265)	2912822..2913076	-	255	WP_247449295.1	hypothetical protein	-
MVF96_RS13270 (MVF96_13270)	2913107..2913397	-	291	WP_243829300.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MVF96_RS13275 (MVF96_13275)	2913394..2913669	-	276	WP_247449296.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MVF96_RS13280 (MVF96_13280)	2913806..2914366	+	561	WP_175404364.1	hypothetical protein	-
MVF96_RS13285 (MVF96_13285)	2914639..2915139	+	501	WP_247449298.1	hypothetical protein	-
MVF96_RS13290 (MVF96_13290)	2915316..2915684	+	369	Protein_2614	arabinosyltransferase C-terminal domain-containing protein	-
MVF96_RS13295 (MVF96_13295)	2915938..2917254	+	1317	WP_014928678.1	IS256 family transposase	-
MVF96_RS13305 (MVF96_13305)	2917544..2917927	+	384	WP_247449299.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2912013..2917254	5241
	-	inside	Genomic island	-	-	2866921..2929382	62461

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (14-94)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10932.34 Da
• Isoelectric Point: 8.6441

>T242405 WP_243829300.1 NZ_CP095552:c2913397-2913107 [Gordonia hongkongensis]
VSDNPTDSADEYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAGNPHRLSKPLRDDLEGLHSARRGDYRILLRIDDPHH
TIVIVKIDHRAHAYRT

Nucleotide

• Length: 291 bp

>T242405 NZ_OW052571:3124163-3124474 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACACCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9770.03 Da
• Isoelectric Point: 4.4638

>AT242405 WP_247449296.1 NZ_CP095552:c2913669-2913394 [Gordonia hongkongensis]
MTTVPLGEAKDKLSALIDSAETTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGIREAVAAADVEYAAGQTVSLE
DLRVEHGMPPQ

Nucleotide

• Length: 276 bp

>AT242405 NZ_OW052571:3123843-3124163 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A