Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1323345..1324018 Replicon chromosome
Accession NZ_CP095552
Organism Gordonia hongkongensis strain JCM 31934

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MVF96_RS05990 Protein ID WP_247451656.1
Coordinates 1323614..1324018 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MVF96_RS05985 Protein ID WP_247451655.1
Coordinates 1323345..1323617 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MVF96_RS05965 (MVF96_05965) 1318402..1318983 - 582 WP_247451651.1 TetR/AcrR family transcriptional regulator -
MVF96_RS05970 (MVF96_05970) 1319059..1320042 + 984 WP_247451652.1 LLM class F420-dependent oxidoreductase -
MVF96_RS05975 (MVF96_05975) 1320266..1321432 - 1167 WP_247451653.1 pyridoxal phosphate-dependent aminotransferase -
MVF96_RS05980 (MVF96_05980) 1321530..1323203 + 1674 WP_247451654.1 serine/threonine-protein kinase -
MVF96_RS05985 (MVF96_05985) 1323345..1323617 + 273 WP_247451655.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MVF96_RS05990 (MVF96_05990) 1323614..1324018 + 405 WP_247451656.1 type II toxin-antitoxin system VapC family toxin Toxin
MVF96_RS05995 (MVF96_05995) 1324020..1325696 - 1677 WP_065631752.1 DEAD/DEAH box helicase -
MVF96_RS06000 (MVF96_06000) 1325763..1326692 - 930 WP_058251650.1 oxygenase MpaB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14166.34 Da        Isoelectric Point: 4.5228

>T242404 WP_247451656.1 NZ_CP095552:1323614-1324018 [Gordonia hongkongensis]
MIYLDTSAMVKLVVREAETAPLIEWLGKYPGVPIVTSALGRVELMRTALHDGSPGLQERARDLLDSLDVVPLSDAVIDIA
ESIGPSSLRSLDALHLASASVIRAEMSAFVAYDHRLIAGASALGYPTVAPGAEL

Download         Length: 405 bp

>T242404 NZ_OW052571:c3115524-3115150 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9865.26 Da        Isoelectric Point: 8.8319

>AT242404 WP_247451655.1 NZ_CP095552:1323345-1323617 [Gordonia hongkongensis]
MRTIGIRELRQHASQYLAQVEAGEELAITNRGRTVARLVPVSAGERSRDALIEAGILVPARRAGGITGLHPETLPTRALT
EVLEQVREDR

Download         Length: 273 bp

>AT242404 NZ_OW052571:c3115718-3115521 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References