Detailed information of TA system TA024240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1806482..1807001
• Replicon: chromosome
• Accession: NC_013192
• Organism: Leptotrichia buccalis C-1013-b

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7NBR1
• Locus tag: LEBU_RS08505
• Protein ID: WP_015769931.1
• Coordinates: 1806482..1806754 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C7NBR2
• Locus tag: LEBU_RS08510
• Protein ID: WP_015769932.1
• Coordinates: 1806747..1807001 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LEBU_RS08475	1802053..1802427	-	375	WP_015769924.1	hypothetical protein	-
LEBU_RS08480	1802475..1803260	-	786	WP_015769925.1	ATP-binding cassette domain-containing protein	-
LEBU_RS08485	1803288..1804028	-	741	WP_015769926.1	hypothetical protein	-
LEBU_RS08490	1803994..1805052	-	1059	WP_015769927.1	3-isopropylmalate dehydrogenase	-
LEBU_RS08495	1805101..1805550	-	450	WP_015769928.1	OmpA family protein	-
LEBU_RS12035	1805681..1806310	-	630	WP_203415693.1	OmpA family protein	-
LEBU_RS11910	1806294..1806467	-	174	WP_015769930.1	hypothetical protein	-
LEBU_RS08505	1806482..1806754	-	273	WP_015769931.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LEBU_RS08510	1806747..1807001	-	255	WP_015769932.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LEBU_RS08515	1807100..1807648	-	549	WP_015769933.1	DUF2262 domain-containing protein	-
LEBU_RS08520	1807929..1808330	-	402	WP_015769934.1	hypothetical protein	-
LEBU_RS08525	1809180..1809647	-	468	WP_015769935.1	hypothetical protein	-
LEBU_RS08530	1809809..1810615	-	807	WP_015769936.1	DUF2262 domain-containing protein	-
LEBU_RS08535	1810650..1811186	-	537	WP_015769937.1	hypothetical protein	-
LEBU_RS08540	1811204..1811779	-	576	WP_015769938.1	3-isopropylmalate dehydratase small subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-73)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 11058.04 Da
• Isoelectric Point: 10.0820

>T24240 WP_015769931.1 NC_013192:c1806754-1806482 [Leptotrichia buccalis C-1013-b]
MLKIRYQVKFKKDYKRAIKRGYNKKLFEEVLFYLVNEKPLPEKYRDHYLTGDYKGFRECHIQPDWLLIYKIEKNILVLTL
SRIGTHSDLF

Nucleotide

• Length: 273 bp

>T24240 NC_013192:c1806754-1806482 [Leptotrichia buccalis C-1013-b]
ATGCTTAAAATCAGGTATCAGGTTAAATTTAAGAAAGATTATAAAAGGGCAATAAAAAGAGGATACAACAAAAAATTATT
TGAAGAAGTTCTTTTTTATTTAGTAAATGAAAAGCCTTTGCCTGAAAAATATAGAGACCATTATCTTACTGGCGATTATA
AAGGATTTAGAGAATGTCATATTCAGCCTGACTGGCTCTTAATTTATAAAATTGAAAAAAATATTTTGGTTTTGACATTG
TCGAGAATAGGGACACATTCTGATTTGTTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9464.06 Da
• Isoelectric Point: 4.8659

>AT24240 WP_015769932.1 NC_013192:c1807001-1806747 [Leptotrichia buccalis C-1013-b]
MATVTARVDENVKKEAETLFKKMGLNMSTAMNLFLKKCILEQGIPFELKVPNKETRKVLDEVEKGVGLSKTFDSIDELME
DLNA

Nucleotide

• Length: 255 bp

>AT24240 NC_013192:c1807001-1806747 [Leptotrichia buccalis C-1013-b]
ATGGCTACAGTAACTGCTAGAGTTGATGAAAATGTGAAAAAAGAAGCAGAAACATTATTTAAAAAAATGGGACTTAATAT
GAGTACAGCAATGAATCTGTTTTTGAAGAAGTGTATTTTGGAGCAGGGGATTCCATTTGAATTGAAAGTTCCTAATAAAG
AAACTAGAAAGGTTTTGGATGAAGTTGAAAAAGGTGTTGGATTAAGTAAAACTTTTGATAGCATAGATGAGTTGATGGAG
GATTTAAATGCTTAA

Structures

Toxin

• AlphaFold DB: C7NBR1

Antitoxin

• AlphaFold DB: C7NBR2