Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2897464..2898295 Replicon chromosome
Accession NZ_CP095540
Organism Escherichia coli strain GN03204

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag MW399_RS13640 Protein ID WP_000854814.1
Coordinates 2897464..2897838 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A641DSP2
Locus tag MW399_RS13645 Protein ID WP_001546021.1
Coordinates 2897927..2898295 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW399_RS13605 (2893459) 2893459..2893788 + 330 WP_000450409.1 DUF496 family protein -
MW399_RS13610 (2893889) 2893889..2894212 - 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
MW399_RS13615 (2894191) 2894191..2894271 + 81 WP_023441679.1 hypothetical protein -
MW399_RS13620 (2894482) 2894482..2896023 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
MW399_RS13625 (2896038) 2896038..2896784 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
MW399_RS13630 (2897147) 2897147..2897227 - 81 Protein_2653 hypothetical protein -
MW399_RS13635 (2897273) 2897273..2897467 - 195 WP_000988601.1 DUF5983 family protein -
MW399_RS13640 (2897464) 2897464..2897838 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
MW399_RS13645 (2897927) 2897927..2898295 - 369 WP_001546021.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
MW399_RS13650 (2898375) 2898375..2898596 - 222 WP_000692323.1 DUF987 domain-containing protein -
MW399_RS13655 (2898659) 2898659..2899135 - 477 WP_001186773.1 RadC family protein -
MW399_RS13660 (2899151) 2899151..2899624 - 474 WP_001385393.1 antirestriction protein -
MW399_RS13665 (2899887) 2899887..2900708 - 822 WP_001234710.1 DUF932 domain-containing protein -
MW399_RS13670 (2900929) 2900929..2901339 - 411 WP_000846704.1 hypothetical protein -
MW399_RS13675 (2901355) 2901355..2902032 - 678 WP_001362823.1 hypothetical protein -
MW399_RS13680 (2902168) 2902168..2903238 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T242391 WP_000854814.1 NZ_CP095540:c2897838-2897464 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T242391 NZ_OW052571:2131961-2132521 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13607.47 Da        Isoelectric Point: 6.3139

>AT242391 WP_001546021.1 NZ_CP095540:c2898295-2897927 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGLFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT242391 NZ_OW052571:2131623-2131964 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A641DSP2

References