Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1798611..1799130 Replicon chromosome
Accession NC_013192
Organism Leptotrichia buccalis C-1013-b

Toxin (Protein)


Gene name relE Uniprot ID C7NBQ0
Locus tag LEBU_RS08445 Protein ID WP_015769920.1
Coordinates 1798611..1798883 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7NBQ1
Locus tag LEBU_RS08450 Protein ID WP_015769921.1
Coordinates 1798876..1799130 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEBU_RS08420 1794187..1794951 - 765 WP_015769916.1 class I SAM-dependent methyltransferase -
LEBU_RS08425 1795131..1796186 - 1056 WP_015769917.1 DMT family transporter -
LEBU_RS08430 1796260..1796634 - 375 WP_015769918.1 hypothetical protein -
LEBU_RS08435 1796682..1797467 - 786 WP_015769919.1 ATP-binding cassette domain-containing protein -
LEBU_RS08440 1797503..1798561 - 1059 WP_006804508.1 3-isopropylmalate dehydrogenase -
LEBU_RS08445 1798611..1798883 - 273 WP_015769920.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
LEBU_RS08450 1798876..1799130 - 255 WP_015769921.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LEBU_RS08455 1799235..1799582 - 348 WP_041760643.1 hypothetical protein -
LEBU_RS08460 1799719..1799976 - 258 WP_041760644.1 hypothetical protein -
LEBU_RS08465 1800097..1801134 - 1038 WP_015769922.1 prolyl oligopeptidase family serine peptidase -
LEBU_RS08470 1801157..1801627 - 471 WP_015769923.1 hypothetical protein -
LEBU_RS08475 1802053..1802427 - 375 WP_015769924.1 hypothetical protein -
LEBU_RS08480 1802475..1803260 - 786 WP_015769925.1 ATP-binding cassette domain-containing protein -
LEBU_RS08485 1803288..1804028 - 741 WP_015769926.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-73)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10986.93 Da        Isoelectric Point: 9.8863

>T24239 WP_015769920.1 NC_013192:c1798883-1798611 [Leptotrichia buccalis C-1013-b]
MLKIRYQVKFKKDYKRAIKRGCNKKLFEEVLFYLVNEKPLPEKYRDHYLTGDYKGFRECHIQPDWLLIYKIEKDILVLTL
SRTGTHSDLF

Download         Length: 273 bp

>T24239 NC_013192:c1798883-1798611 [Leptotrichia buccalis C-1013-b]
ATGCTTAAAATCAGATACCAGGTTAAATTCAAGAAAGATTATAAAAGGGCAATAAAAAGAGGGTGTAACAAAAAATTATT
TGAAGAAGTCCTTTTTTATTTGGTAAATGAGAAACCTTTGCCTGAAAAATATAGAGATCATTATCTTACTGGCGATTATA
AAGGATTTAGAGAATGTCATATTCAGCCTGATTGGTTGTTAATTTATAAAATTGAAAAAGATATTTTGGTTTTAACGTTG
TCAAGAACAGGAACACATTCTGATTTATTTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9407.91 Da        Isoelectric Point: 4.4012

>AT24239 WP_015769921.1 NC_013192:c1799130-1798876 [Leptotrichia buccalis C-1013-b]
MATVTARVDENVKKEAETLFKKMGLNMSTAMNLFLKKCILEQGIPFELKVPNGETRKVLDEVEKGIGLSETFDSIDELME
DLNA

Download         Length: 255 bp

>AT24239 NC_013192:c1799130-1798876 [Leptotrichia buccalis C-1013-b]
ATGGCTACAGTAACAGCTAGAGTTGATGAAAATGTGAAAAAAGAAGCGGAAACTTTATTTAAAAAAATGGGGCTTAATAT
GAGTACTGCTATGAATTTATTTTTGAAGAAGTGTATTTTGGAGCAGGGGATTCCGTTTGAGTTGAAAGTTCCAAATGGAG
AAACCAGAAAGGTTTTGGATGAAGTTGAAAAAGGTATTGGGTTAAGCGAAACTTTTGATAGTATAGATGAGTTGATGGAG
GATTTGAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510KJI4

Antitoxin

Source ID Structure
AlphaFold DB C7NBQ1

References