Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1820621..1821455 | Replicon | chromosome |
| Accession | NZ_CP095540 | ||
| Organism | Escherichia coli strain GN03204 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | MW399_RS08685 | Protein ID | WP_001546109.1 |
| Coordinates | 1820621..1820998 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7I0L0C8 |
| Locus tag | MW399_RS08690 | Protein ID | WP_001546108.1 |
| Coordinates | 1821075..1821455 (-) | Length | 127 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MW399_RS08655 (1817015) | 1817015..1817185 | - | 171 | Protein_1682 | IS110 family transposase | - |
| MW399_RS08660 (1817602) | 1817602..1818536 | - | 935 | Protein_1683 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| MW399_RS08665 (1818529) | 1818529..1818924 | - | 396 | WP_000208383.1 | DUF6088 family protein | - |
| MW399_RS08670 (1818993) | 1818993..1819838 | - | 846 | WP_001280441.1 | DUF4942 domain-containing protein | - |
| MW399_RS08675 (1819923) | 1819923..1820120 | - | 198 | WP_000839260.1 | DUF957 domain-containing protein | - |
| MW399_RS08680 (1820137) | 1820137..1820624 | - | 488 | Protein_1687 | DUF5983 family protein | - |
| MW399_RS08685 (1820621) | 1820621..1820998 | - | 378 | WP_001546109.1 | TA system toxin CbtA family protein | Toxin |
| MW399_RS08690 (1821075) | 1821075..1821455 | - | 381 | WP_001546108.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MW399_RS08695 (1821505) | 1821505..1822149 | - | 645 | WP_000086755.1 | hypothetical protein | - |
| MW399_RS08700 (1822168) | 1822168..1822389 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| MW399_RS08705 (1822458) | 1822458..1822934 | - | 477 | WP_001424026.1 | RadC family protein | - |
| MW399_RS08710 (1822950) | 1822950..1823087 | - | 138 | Protein_1693 | antirestriction protein | - |
| MW399_RS08715 (1823175) | 1823175..1823600 | + | 426 | WP_000422741.1 | transposase | - |
| MW399_RS08720 (1823597) | 1823597..1823947 | + | 351 | WP_000624722.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| MW399_RS08725 (1823978) | 1823978..1825591 | + | 1614 | WP_000080195.1 | IS66-like element ISEc23 family transposase | - |
| MW399_RS08730 (1825622) | 1825622..1825975 | - | 354 | Protein_1697 | antirestriction protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13986.00 Da Isoelectric Point: 8.5190
>T242388 WP_001546109.1 NZ_CP095540:c1820998-1820621 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYKMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYKMVNNITQGKHPEAKR
Download Length: 378 bp
>T242388 NZ_OW052571:c2044203-2043793 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA
Antitoxin
Download Length: 127 a.a. Molecular weight: 13997.78 Da Isoelectric Point: 5.0823
>AT242388 WP_001546108.1 NZ_CP095540:c1821455-1821075 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFNNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFNNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
Download Length: 381 bp
>AT242388 NZ_OW052571:c2044429-2044196 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|