24238

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 1265283..1265802 Replicon chromosome
Accession NC_013192
Organism Leptotrichia buccalis C-1013-b

Toxin (Protein)


Gene name yoeB Uniprot ID C7NA91
Locus tag LEBU_RS05840 Protein ID WP_006804080.1
Coordinates 1265545..1265802 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID C7NA90
Locus tag LEBU_RS05835 Protein ID WP_015769415.1
Coordinates 1265283..1265540 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEBU_RS05815 1260533..1261069 + 537 WP_015769411.1 HEAT repeat domain-containing protein -
LEBU_RS05820 1261066..1261638 + 573 WP_041760573.1 DUF4291 domain-containing protein -
LEBU_RS05825 1261923..1263023 + 1101 WP_049756122.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
LEBU_RS05830 1263084..1265126 + 2043 WP_015769414.1 PBP1A family penicillin-binding protein -
LEBU_RS05835 1265283..1265540 + 258 WP_015769415.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LEBU_RS05840 1265545..1265802 + 258 WP_006804080.1 Txe/YoeB family addiction module toxin Toxin
LEBU_RS05845 1265906..1267285 - 1380 WP_015769416.1 NCS2 family permease -
LEBU_RS05850 1267328..1268680 - 1353 WP_015769417.1 hemolysin family protein -
LEBU_RS05855 1268896..1269369 - 474 WP_015769418.1 GNAT family N-acetyltransferase -
LEBU_RS05860 1269864..1270337 - 474 WP_015769419.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1217886..1380800 162914


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10162.63 Da        Isoelectric Point: 9.7099

>T24238 WP_006804080.1 NC_013192:1265545-1265802 [Leptotrichia buccalis C-1013-b]
MNINWNSEAWKEYVDWQSKDKKVIKKINEIIKDIQRNGNEGIGKAEALKHELSGYWSRRITDKHRFIYKLTENEVIIIAC
ANHYK

Download         Length: 258 bp

>T24238 NC_013192:1265545-1265802 [Leptotrichia buccalis C-1013-b]
ATGAACATAAATTGGAATAGTGAAGCATGGAAGGAATATGTAGACTGGCAATCAAAAGATAAAAAAGTTATAAAAAAGAT
AAATGAAATTATAAAGGATATTCAGAGAAATGGAAATGAAGGAATAGGTAAAGCAGAGGCTTTAAAGCATGAATTAAGTG
GGTATTGGAGCAGAAGAATAACTGATAAGCACAGATTTATTTATAAATTGACTGAAAATGAAGTTATAATAATAGCTTGT
GCTAATCATTACAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10291.60 Da        Isoelectric Point: 4.7473

>AT24238 WP_015769415.1 NC_013192:1265283-1265540 [Leptotrichia buccalis C-1013-b]
MIATNYSNIRNNFKKYCDKATRDYETIIVTRKNDENVVLMSEEEYNNLMENLYIMSNKDYYNELLKRKDEVEKGKVEKHD
LIEVE

Download         Length: 258 bp

>AT24238 NC_013192:1265283-1265540 [Leptotrichia buccalis C-1013-b]
ATGATAGCTACAAATTATTCTAATATTAGAAATAATTTTAAAAAGTATTGTGATAAGGCAACAAGAGATTATGAAACAAT
AATTGTAACTAGAAAAAATGATGAAAATGTGGTATTAATGAGTGAAGAAGAATACAATAATTTGATGGAAAATTTGTATA
TTATGTCTAATAAAGATTATTATAATGAATTATTGAAAAGAAAAGATGAGGTTGAAAAAGGGAAAGTTGAGAAACATGAT
TTAATTGAGGTGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C7NA91

Antitoxin

Source ID Structure
AlphaFold DB A0A510JH14

References