Detailed information of TA system TA242367

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3030756..3031461
• Replicon: chromosome
• Accession: NZ_CP095538
• Organism: Escherichia coli strain GN04592

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: MW396_RS15085
• Protein ID: WP_000539521.1
• Coordinates: 3030756..3031142 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MW396_RS15090
• Protein ID: WP_001280945.1
• Coordinates: 3031132..3031461 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW396_RS15065 (3026760)	3026760..3027386	+	627	WP_001295292.1	glutathione S-transferase GstB	-
MW396_RS15070 (3027383)	3027383..3028498	-	1116	WP_000555038.1	aldose sugar dehydrogenase YliI	-
MW396_RS15075 (3028609)	3028609..3028992	-	384	WP_000497137.1	biofilm formation regulator BssR	-
MW396_RS15080 (3029205)	3029205..3030530	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
MW396_RS15085 (3030756)	3030756..3031142	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MW396_RS15090 (3031132)	3031132..3031461	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
MW396_RS15095 (3031531)	3031531..3032859	-	1329	WP_000086879.1	GGDEF domain-containing protein	-
MW396_RS15100 (3032867)	3032867..3035215	-	2349	WP_001322378.1	EAL domain-containing protein	-
MW396_RS15105 (3035393)	3035393..3036304	-	912	WP_001236042.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T242367 WP_000539521.1 NZ_CP095538:3030756-3031142 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T242367 NZ_OW052571:c538949-538539 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT242367 WP_001280945.1 NZ_CP095538:3031132-3031461 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT242367 NZ_OW052571:c539224-538946 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: A0A829GCT6