Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1630188..1631019 | Replicon | chromosome |
| Accession | NZ_CP095538 | ||
| Organism | Escherichia coli strain GN04592 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | MW396_RS07730 | Protein ID | WP_064772430.1 |
| Coordinates | 1630188..1630562 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B3Y195 |
| Locus tag | MW396_RS07735 | Protein ID | WP_001285585.1 |
| Coordinates | 1630651..1631019 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MW396_RS07690 (1625584) | 1625584..1626750 | + | 1167 | WP_000830156.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| MW396_RS07695 (1626869) | 1626869..1627342 | + | 474 | WP_001105415.1 | DNA gyrase inhibitor SbmC | - |
| MW396_RS07700 (1627540) | 1627540..1628598 | + | 1059 | WP_001200891.1 | FUSC family protein | - |
| MW396_RS07705 (1628770) | 1628770..1629099 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| MW396_RS07710 (1629200) | 1629200..1629523 | - | 324 | WP_225343796.1 | EutP/PduV family microcompartment system protein | - |
| MW396_RS07715 (1629502) | 1629502..1629582 | + | 81 | WP_023441679.1 | hypothetical protein | - |
| MW396_RS07720 (1629871) | 1629871..1629951 | - | 81 | Protein_1507 | hypothetical protein | - |
| MW396_RS07725 (1629997) | 1629997..1630191 | - | 195 | WP_000988600.1 | DUF5983 family protein | - |
| MW396_RS07730 (1630188) | 1630188..1630562 | - | 375 | WP_064772430.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| MW396_RS07735 (1630651) | 1630651..1631019 | - | 369 | WP_001285585.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| MW396_RS07740 (1631093) | 1631093..1631314 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| MW396_RS07745 (1631377) | 1631377..1631853 | - | 477 | WP_001186724.1 | RadC family protein | - |
| MW396_RS07750 (1631869) | 1631869..1632354 | - | 486 | WP_001469549.1 | antirestriction protein | - |
| MW396_RS07755 (1632409) | 1632409..1633227 | - | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| MW396_RS07760 (1633327) | 1633327..1633560 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| MW396_RS07765 (1633639) | 1633639..1634094 | - | 456 | WP_000581504.1 | IrmA family protein | - |
| MW396_RS07770 (1634170) | 1634170..1634751 | - | 582 | Protein_1517 | hypothetical protein | - |
| MW396_RS07775 (1634808) | 1634808..1635602 | - | 795 | WP_000544809.1 | IS21-like element helper ATPase IstB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13894.95 Da Isoelectric Point: 7.8522
>T242354 WP_064772430.1 NZ_CP095538:c1630562-1630188 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMPRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMPRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T242354 NZ_OW052570:3561029-3561385 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13593.48 Da Isoelectric Point: 6.3139
>AT242354 WP_001285585.1 NZ_CP095538:c1631019-1630651 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT242354 NZ_OW052570:3560815-3561045 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|