Detailed information of TA system TA024235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/RHH(antitoxin)
• Location: 2933735..2934306
• Replicon: chromosome
• Accession: NC_013173
• Organism: Desulfomicrobium baculatum DSM 4028

Toxin (Protein)

• Gene name: parE
• Uniprot ID: C7LSA5
• Locus tag: DBAC_RS12880
• Protein ID: WP_015774742.1
• Coordinates: 2934016..2934306 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: C7LSA4
• Locus tag: DBAC_RS12875
• Protein ID: WP_015774741.1
• Coordinates: 2933735..2934028 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBAC_RS12835	2929198..2929467	+	270	WP_015774733.1	DUF4160 domain-containing protein	-
DBAC_RS12840	2929484..2929741	+	258	WP_015774734.1	DUF2442 domain-containing protein	-
DBAC_RS12845	2930161..2930508	+	348	WP_015774735.1	four helix bundle protein	-
DBAC_RS12850	2930597..2930917	+	321	WP_043812677.1	helix-turn-helix domain-containing protein	-
DBAC_RS12860	2931233..2931562	+	330	WP_015774737.1	HigA family addiction module antidote protein	-
DBAC_RS12865	2931776..2932108	+	333	WP_015774738.1	type II toxin-antitoxin system HicB family antitoxin	-
DBAC_RS12870	2932239..2933264	-	1026	WP_015774739.1	hypothetical protein	-
DBAC_RS12875	2933735..2934028	+	294	WP_015774741.1	CopG family transcriptional regulator	Antitoxin
DBAC_RS12880	2934016..2934306	+	291	WP_015774742.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DBAC_RS12885	2934489..2934812	-	324	WP_015774743.1	PilZ domain-containing protein	-
DBAC_RS19385	2934824..2934982	-	159	WP_015774744.1	hypothetical protein	-
DBAC_RS12890	2935351..2937711	-	2361	WP_015774745.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10629.22 Da
• Isoelectric Point: 6.7089

>T24235 WP_015774742.1 NC_013173:2934016-2934306 [Desulfomicrobium baculatum DSM 4028]
MPRLIWTAGAVDGLGKIHRFLAEKDAQAAAKALDAIRKGANILRYFPQAGRPTEDLEPEHRELLIPFGASGYAVFYETID
DCVCILTVKHQKEAGY

Nucleotide

• Length: 291 bp

>T24235 NC_013173:2934016-2934306 [Desulfomicrobium baculatum DSM 4028]
ATGCCACGTCTGATCTGGACCGCGGGGGCCGTTGACGGACTCGGTAAAATCCACCGCTTTCTTGCCGAAAAGGATGCGCA
GGCCGCTGCGAAAGCCCTGGACGCCATCCGCAAGGGAGCAAACATCCTGCGATACTTTCCCCAGGCCGGACGCCCGACGG
AGGACCTGGAACCGGAACATCGCGAATTGCTCATCCCGTTCGGGGCTTCAGGCTACGCCGTTTTCTACGAAACCATCGAC
GACTGCGTATGCATCCTCACCGTCAAACATCAGAAAGAAGCGGGATACTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11173.87 Da
• Isoelectric Point: 5.9026

>AT24235 WP_015774741.1 NC_013173:2933735-2934028 [Desulfomicrobium baculatum DSM 4028]
MPSQGPIKPTSIKLPLELHARVQHIAMVRKRSVHEVMIRAMETYVDREEKREAIRQECIKAHDEYMLTGLHVTGEEVDAW
IDQLVDGNETEMPACHV

Nucleotide

• Length: 294 bp

>AT24235 NC_013173:2933735-2934028 [Desulfomicrobium baculatum DSM 4028]
ATGCCCTCGCAAGGACCGATCAAGCCCACGAGCATCAAGCTTCCCCTGGAATTGCACGCACGCGTGCAGCACATTGCCAT
GGTCCGCAAGCGTTCGGTTCATGAAGTCATGATCAGGGCGATGGAGACCTATGTGGACAGGGAGGAGAAGCGGGAGGCCA
TCCGTCAGGAGTGTATCAAGGCCCACGACGAGTATATGCTGACCGGACTGCATGTCACAGGCGAAGAGGTAGACGCATGG
ATTGATCAACTCGTTGATGGCAACGAGACGGAAATGCCCGCATGCCACGTCTGA

Structures

Toxin

• AlphaFold DB: C7LSA5

Antitoxin

• AlphaFold DB: C7LSA4