Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 91414..91961 Replicon plasmid p2461-1
Accession NZ_CP095535
Organism Escherichia coli strain GN02461

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag MW400_RS24950 Protein ID WP_001384452.1
Coordinates 91683..91961 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag MW400_RS24945 Protein ID WP_000079941.1
Coordinates 91414..91683 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW400_RS24930 (86714) 86714..87064 + 351 WP_000454193.1 DUF3330 domain-containing protein -
MW400_RS24935 (87240) 87240..87800 + 561 WP_001161490.1 recombinase family protein -
MW400_RS24940 (87804) 87804..90770 + 2967 WP_001138014.1 Tn3-like element TnAs1 family transposase -
MW400_RS24945 (91414) 91414..91683 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
MW400_RS24950 (91683) 91683..91961 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
MW400_RS24955 (92007) 92007..92855 + 849 WP_001057989.1 3'-5' exonuclease -
MW400_RS24960 (93041) 93041..94921 + 1881 WP_001283335.1 colicin Ia central receptor-binding domain-containing protein -
MW400_RS24965 (94943) 94943..95278 - 336 WP_001080729.1 colicin 1A immunity protein -
MW400_RS24970 (95407) 95407..95622 + 216 Protein_110 DUF6404 family protein -
MW400_RS24975 (95684) 95684..96274 - 591 WP_001518980.1 hypothetical protein -
MW400_RS24980 (96271) 96271..96531 - 261 WP_000343091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B / dfrA5 / sitABCD iucA / iucB / iucC / iucD / iutA / iroN / iroE / iroD / iroC / iroB 1..148943 148943


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T242347 WP_001384452.1 NZ_CP095535:91683-91961 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T242347 NZ_OW052570:c2898075-2897818 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT242347 WP_000079941.1 NZ_CP095535:91414-91683 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT242347 NZ_OW052570:c2898347-2898072 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References