Detailed information of TA system TA024234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 2896830..2897404
• Replicon: chromosome
• Accession: NC_013173
• Organism: Desulfomicrobium baculatum DSM 4028

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: C7LS69
• Locus tag: DBAC_RS12715
• Protein ID: WP_015774706.1
• Coordinates: 2896830..2897165 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: C7LS70
• Locus tag: DBAC_RS12720
• Protein ID: WP_015774707.1
• Coordinates: 2897165..2897404 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBAC_RS12665	2892166..2892558	-	393	WP_015774697.1	type II toxin-antitoxin system VapC family toxin	-
DBAC_RS12670	2892555..2892797	-	243	WP_015774698.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
DBAC_RS12675	2892956..2893234	+	279	WP_015774699.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
DBAC_RS12680	2893224..2893493	+	270	WP_015774700.1	Txe/YoeB family addiction module toxin	-
DBAC_RS12690	2894355..2895521	+	1167	WP_043810959.1	Fic family protein	-
DBAC_RS18485	2895534..2895850	+	317	Protein_2503	helix-turn-helix transcriptional regulator	-
DBAC_RS12700	2895952..2896122	+	171	Protein_2504	Txe/YoeB family addiction module toxin	-
DBAC_RS12705	2896167..2896448	-	282	WP_043810969.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DBAC_RS12710	2896450..2896695	-	246	WP_015774705.1	CopG family transcriptional regulator	-
DBAC_RS12715	2896830..2897165	-	336	WP_015774706.1	endoribonuclease MazF	Toxin
DBAC_RS12720	2897165..2897404	-	240	WP_015774707.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DBAC_RS19455	2897854..2898438	-	585	WP_015774708.1	hypothetical protein	-
DBAC_RS12730	2899071..2899748	+	678	WP_015774709.1	hypothetical protein	-
DBAC_RS18495	2899902..2900168	-	267	WP_081434438.1	excalibur calcium-binding domain-containing protein	-
DBAC_RS12735	2900430..2901059	-	630	WP_043810983.1	VPLPA-CTERM sorting domain-containing protein	-
DBAC_RS12740	2901226..2902014	-	789	WP_050762094.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-106)

Antitoxin

• Antitoxin PemI-like (1-78)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12176.97 Da
• Isoelectric Point: 6.2137

>T24234 WP_015774706.1 NC_013173:c2897165-2896830 [Desulfomicrobium baculatum DSM 4028]
MYVPDRGHAVWMNFTPQAGHEQAGHRPALVISPASYNGRTGLLLCCPITSQIKGYPFEVRIEGNPLISGVALADQITNLD
WRVRGVKFVASVDESVLEEVVAKFEALLRGE

Nucleotide

• Length: 336 bp

>T24234 NC_013173:c2897165-2896830 [Desulfomicrobium baculatum DSM 4028]
ATGTACGTCCCCGATCGCGGCCATGCCGTATGGATGAATTTCACCCCCCAGGCCGGACATGAACAGGCGGGCCATCGCCC
GGCGCTGGTGATCTCGCCCGCTTCGTATAACGGGCGGACAGGGCTGTTGCTGTGCTGCCCAATCACGAGCCAGATCAAGG
GCTACCCTTTCGAGGTCCGGATTGAAGGCAACCCATTGATCTCGGGTGTTGCGCTGGCGGATCAGATCACGAATCTGGAT
TGGCGGGTGCGGGGGGTCAAGTTCGTAGCCTCGGTGGACGAGTCTGTGCTCGAAGAGGTTGTCGCCAAGTTTGAGGCGTT
GCTGAGGGGGGAATAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8684.06 Da
• Isoelectric Point: 5.0506

>AT24234 WP_015774707.1 NC_013173:c2897404-2897165 [Desulfomicrobium baculatum DSM 4028]
MEAKTVKWGNSLALRIPNSIVKDCGLSENSLVDISFRKGEIVIKPMRGRYALSELLAGITPENVHGEAFMDEPVGQELL

Nucleotide

• Length: 240 bp

>AT24234 NC_013173:c2897404-2897165 [Desulfomicrobium baculatum DSM 4028]
ATGGAAGCCAAAACCGTCAAATGGGGCAACAGTCTGGCCCTCAGAATACCAAACTCCATCGTCAAGGATTGTGGTCTTTC
CGAGAATTCGCTCGTCGATATCTCATTTAGAAAGGGCGAGATCGTTATCAAACCCATGCGCGGGAGGTACGCGCTCAGCG
AGTTGCTGGCCGGGATAACCCCGGAGAATGTCCATGGCGAGGCCTTCATGGACGAGCCCGTGGGCCAGGAGCTGCTGTAA

Structures

Toxin

• AlphaFold DB: C7LS69

Antitoxin

• AlphaFold DB: C7LS70