Detailed information of TA system TA024233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 2887127..2887640
• Replicon: chromosome
• Accession: NC_013173
• Organism: Desulfomicrobium baculatum DSM 4028

Toxin (Protein)

• Gene name: -
• Uniprot ID: C7LS54
• Locus tag: DBAC_RS12630
• Protein ID: WP_015774691.1
• Coordinates: 2887127..2887390 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: C7LS55
• Locus tag: DBAC_RS12635
• Protein ID: WP_015774692.1
• Coordinates: 2887380..2887640 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBAC_RS12605	2882385..2883410	+	1026	WP_015774687.1	cytochrome d ubiquinol oxidase subunit II	-
DBAC_RS12610	2883546..2884718	-	1173	WP_015774688.1	TraB/GumN family protein	-
DBAC_RS12615	2884887..2886272	+	1386	WP_015774689.1	MATE family efflux transporter	-
DBAC_RS12620	2886269..2886565	+	297	WP_015774690.1	hypothetical protein	-
DBAC_RS19245	2886570..2886731	+	162	WP_153304565.1	hypothetical protein	-
DBAC_RS12630	2887127..2887390	+	264	WP_015774691.1	BrnT family toxin	Toxin
DBAC_RS12635	2887380..2887640	+	261	WP_015774692.1	CopG family transcriptional regulator	Antitoxin
DBAC_RS12640	2887834..2888559	+	726	WP_143890929.1	hypothetical protein	-
DBAC_RS12645	2888579..2891125	+	2547	WP_167320940.1	hypothetical protein	-
DBAC_RS12650	2891204..2891599	-	396	WP_015774695.1	PIN domain nuclease	-
DBAC_RS12655	2891596..2891790	-	195	WP_015774696.1	type II toxin-antitoxin system VapB family antitoxin	-
DBAC_RS12665	2892166..2892558	-	393	WP_015774697.1	type II toxin-antitoxin system VapC family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9938.14 Da
• Isoelectric Point: 5.6938

>T24233 WP_015774691.1 NC_013173:2887127-2887390 [Desulfomicrobium baculatum DSM 4028]
MSAFEYDEAKSQANLEKHGISFSDAQAIWADPDALEVQARSEDEPRFLVIGMIGQKHWSAVVTYRGTITRLISVRRSRKS
EVYLYES

Nucleotide

• Length: 264 bp

>T24233 NC_013173:2887127-2887390 [Desulfomicrobium baculatum DSM 4028]
ATGAGCGCTTTCGAATACGATGAGGCCAAGAGCCAGGCCAATCTGGAAAAGCATGGAATCAGCTTTTCGGATGCCCAGGC
TATATGGGCCGACCCTGACGCACTGGAGGTCCAGGCAAGGTCGGAGGATGAACCCAGATTTCTGGTCATCGGCATGATTG
GCCAAAAGCATTGGTCTGCCGTCGTCACCTATCGAGGCACAATCACCCGTCTCATCTCAGTCAGGCGCTCCCGAAAAAGC
GAGGTATATCTGTATGAAAGCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9848.27 Da
• Isoelectric Point: 8.5416

>AT24233 WP_015774692.1 NC_013173:2887380-2887640 [Desulfomicrobium baculatum DSM 4028]
MKAKDFDKKFDQGTEDIMSSLDLSTARRVNQEQRRINVDFPVWVVDSLDREAARIGVTRQSIIKVWLVERLKAEAANKCH
ACAAEK

Nucleotide

• Length: 261 bp

>AT24233 NC_013173:2887380-2887640 [Desulfomicrobium baculatum DSM 4028]
ATGAAAGCTAAAGATTTCGACAAGAAGTTTGACCAGGGCACTGAGGACATCATGAGCAGCCTTGATCTGTCCACAGCACG
TCGCGTCAACCAGGAGCAGCGGCGGATCAACGTCGACTTTCCCGTTTGGGTAGTGGACTCTCTGGACCGTGAGGCGGCCA
GGATTGGCGTCACACGGCAGTCAATTATCAAGGTCTGGCTGGTTGAACGCCTAAAAGCGGAAGCCGCCAATAAGTGCCAC
GCCTGCGCAGCCGAAAAATAG

Structures

Toxin

• AlphaFold DB: C7LS54

Antitoxin

• AlphaFold DB: C7LS55