Detailed information of TA system TA242320

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 840936..841531
• Replicon: chromosome
• Accession: NZ_CP095533
• Organism: Escherichia coli strain GN02461

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: MW400_RS03805
• Protein ID: WP_000239581.1
• Coordinates: 841181..841531 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: V0YZQ7
• Locus tag: MW400_RS03800
• Protein ID: WP_001223206.1
• Coordinates: 840936..841187 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW400_RS03790 (836601)	836601..840380	+	3780	WP_000060869.1	autotransporter assembly complex protein TamB	-
MW400_RS03795 (840383)	840383..840724	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
MW400_RS03800 (840936)	840936..841187	+	252	WP_001223206.1	type II toxin-antitoxin system ChpS family antitoxin	Antitoxin
MW400_RS03805 (841181)	841181..841531	+	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
MW400_RS03810 (841610)	841610..842140	-	531	WP_000055075.1	inorganic diphosphatase	-
MW400_RS03815 (842450)	842450..843406	+	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
MW400_RS03820 (843548)	843548..845050	+	1503	WP_001095668.1	sugar ABC transporter ATP-binding protein	-
MW400_RS03825 (845064)	845064..846086	+	1023	WP_001445811.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T242320 WP_000239581.1 NZ_CP095533:841181-841531 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T242320 NZ_OW052570:c716994-716173 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9303.62 Da
• Isoelectric Point: 4.6509

>AT242320 WP_001223206.1 NZ_CP095533:840936-841187 [Escherichia coli]
MRITIKKWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT242320 NZ_OW052570:c716171-715944 [Mycobacterium tuberculosis]
GTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCAAGAAGCGAT
GGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGTCGTTGGGAA
CCCTGAAGCAAACGCATTCGCGGTACTTCACTAGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: V0YZQ7