Detailed information of TA system TA024232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2601102..2601627
• Replicon: chromosome
• Accession: NC_013173
• Organism: Desulfomicrobium baculatum DSM 4028

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7LQD8
• Locus tag: DBAC_RS11310
• Protein ID: WP_015774429.1
• Coordinates: 2601340..2601627 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C7LQD7
• Locus tag: DBAC_RS11305
• Protein ID: WP_015774428.1
• Coordinates: 2601102..2601350 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBAC_RS11295	2596384..2597736	-	1353	WP_015774426.1	phosphomannomutase/phosphoglucomutase	-
DBAC_RS11300	2598091..2600904	+	2814	WP_015774427.1	FAD-binding oxidoreductase	-
DBAC_RS11305	2601102..2601350	+	249	WP_015774428.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DBAC_RS11310	2601340..2601627	+	288	WP_015774429.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DBAC_RS11315	2601781..2601969	+	189	WP_015774430.1	twin-arginine translocase TatA/TatE family subunit	-
DBAC_RS11320	2602293..2602874	+	582	WP_015774431.1	TlpA family protein disulfide reductase	-
DBAC_RS11325	2602886..2603485	+	600	WP_015774432.1	redoxin domain-containing protein	-
DBAC_RS11330	2603627..2604136	+	510	WP_015774433.1	nitroreductase family protein	-
DBAC_RS11335	2604315..2605391	-	1077	WP_015774434.1	sigma-54 dependent transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11230.17 Da
• Isoelectric Point: 10.9851

>T24232 WP_015774429.1 NC_013173:2601340-2601627 [Desulfomicrobium baculatum DSM 4028]
MTYSLRFKEEAKKEWDRLDPVIREHFAKKLRQRRENPRVNSARLSGMPDCFKIKLRSAGYRLVYEVRDHEVVIVVIAVGK
RERSAVYKIAAKRLG

Nucleotide

• Length: 288 bp

>T24232 NC_013173:2601340-2601627 [Desulfomicrobium baculatum DSM 4028]
ATGACCTATAGCCTGCGTTTCAAGGAAGAGGCCAAAAAGGAATGGGACAGGCTTGATCCCGTCATCCGTGAGCATTTCGC
CAAAAAACTGCGCCAGCGGCGCGAGAACCCAAGGGTAAACAGCGCGAGGCTCTCGGGCATGCCAGACTGCTTCAAGATCA
AGCTCCGCAGCGCCGGTTACAGACTTGTTTACGAGGTCCGCGACCACGAGGTGGTCATTGTCGTGATCGCGGTGGGAAAG
CGTGAACGCAGCGCGGTGTACAAGATCGCGGCCAAAAGACTGGGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8911.26 Da
• Isoelectric Point: 4.0466

>AT24232 WP_015774428.1 NC_013173:2601102-2601350 [Desulfomicrobium baculatum DSM 4028]
MPNMILADVAASVSELKKNPMATVAAGEGFPVAILNHNEPVFYCVPAHAYEALMDKLEDMELAALAVARKDQPEIEVAWD
DL

Nucleotide

• Length: 249 bp

>AT24232 NC_013173:2601102-2601350 [Desulfomicrobium baculatum DSM 4028]
ATGCCCAACATGATCCTTGCCGATGTGGCGGCCAGCGTATCGGAACTCAAGAAAAACCCCATGGCCACCGTAGCCGCAGG
CGAGGGCTTCCCCGTGGCCATCCTCAACCACAACGAACCGGTCTTCTACTGCGTGCCGGCTCATGCATACGAAGCCCTCA
TGGACAAGCTCGAAGACATGGAGCTTGCAGCCCTGGCCGTCGCCCGCAAGGATCAGCCGGAGATCGAGGTGGCCTGGGAT
GACCTATAG

Structures

Toxin

• AlphaFold DB: C7LQD8

Antitoxin

• AlphaFold DB: C7LQD7