Detailed information of TA system TA024231

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1539342..1539931
• Replicon: chromosome
• Accession: NC_013173
• Organism: Desulfomicrobium baculatum DSM 4028

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: C7LSS4
• Locus tag: DBAC_RS06865
• Protein ID: WP_015773559.1
• Coordinates: 1539677..1539931 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: C7LSS3
• Locus tag: DBAC_RS06860
• Protein ID: WP_015773558.1
• Coordinates: 1539342..1539680 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBAC_RS06830	1535159..1535404	-	246	WP_050762058.1	universal stress protein	-
DBAC_RS06835	1535414..1535635	-	222	WP_015773553.1	hypothetical protein	-
DBAC_RS06840	1535673..1535900	-	228	WP_015773554.1	hypothetical protein	-
DBAC_RS06845	1536150..1537514	+	1365	WP_015773555.1	sigma-54-dependent Fis family transcriptional regulator	-
DBAC_RS06850	1537772..1538887	+	1116	WP_015773556.1	Fic family protein	-
DBAC_RS06855	1538971..1539222	+	252	WP_015773557.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
DBAC_RS06860	1539342..1539680	-	339	WP_015773558.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DBAC_RS06865	1539677..1539931	-	255	WP_015773559.1	type II toxin-antitoxin system HicA family toxin	Toxin
DBAC_RS06870	1540102..1542486	-	2385	WP_015773560.1	FAD-dependent oxidoreductase	-
DBAC_RS06875	1542499..1544133	-	1635	WP_015773561.1	4Fe-4S binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (56-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9536.94 Da
• Isoelectric Point: 10.3839

>T24231 WP_015773559.1 NC_013173:c1539931-1539677 [Desulfomicrobium baculatum DSM 4028]
MKRKHESTLRRIFDHPTSGGIKWADIEALFAELGAEIAEREGSRISVFLFGEIRIFHRPHPSPDKDKGAVASIRKWLETN
GVKP

Nucleotide

• Length: 255 bp

>T24231 NC_013173:c1539931-1539677 [Desulfomicrobium baculatum DSM 4028]
ATGAAACGCAAACACGAATCCACTCTCCGCAGGATTTTTGACCATCCGACATCTGGCGGGATCAAATGGGCAGATATCGA
GGCCTTGTTTGCGGAGCTGGGAGCGGAAATAGCGGAGCGTGAAGGTTCGCGCATCAGCGTGTTTCTTTTTGGAGAGATCA
GAATCTTCCATCGCCCGCATCCTTCGCCGGACAAGGACAAGGGCGCGGTGGCAAGCATCAGGAAGTGGCTCGAAACGAAT
GGGGTGAAGCCATGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12110.80 Da
• Isoelectric Point: 5.2069

>AT24231 WP_015773558.1 NC_013173:c1539680-1539342 [Desulfomicrobium baculatum DSM 4028]
MKNVLDFPGGYSAVIGYDSELEMFRGEFVGLNGGADFYATDLEGLKREGALSLKVFLDECAARGIEPKKAKGKFALRLDQ
DIYRQATIAAAASGKSLNQFITEAVREAVARA

Nucleotide

• Length: 339 bp

>AT24231 NC_013173:c1539680-1539342 [Desulfomicrobium baculatum DSM 4028]
ATGAAGAACGTACTTGATTTTCCCGGCGGTTACTCTGCCGTCATTGGCTACGATTCCGAGCTGGAAATGTTCCGGGGAGA
ATTTGTCGGCTTGAATGGCGGAGCCGACTTCTACGCCACGGACCTGGAAGGACTCAAGCGAGAAGGCGCGTTGTCGCTCA
AGGTCTTTTTGGACGAATGCGCCGCACGTGGCATCGAGCCCAAAAAGGCAAAAGGAAAATTCGCCCTGCGCCTGGATCAG
GACATCTACCGCCAGGCCACTATCGCCGCCGCCGCCAGCGGAAAAAGCCTGAACCAGTTCATCACCGAAGCCGTGCGCGA
AGCCGTGGCCCGCGCATGA

Structures

Toxin

• AlphaFold DB: C7LSS4

Antitoxin

• AlphaFold DB: C7LSS3