Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2345557..2346195 Replicon chromosome
Accession NZ_CP095529
Organism Escherichia coli strain GN06156

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MW397_RS11205 Protein ID WP_064772903.1
Coordinates 2345557..2345733 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MW397_RS11210 Protein ID WP_076611057.1
Coordinates 2345779..2346195 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW397_RS11185 (2341179) 2341179..2342390 - 1212 WP_001323162.1 BenE family transporter YdcO -
MW397_RS11190 (2342443) 2342443..2342979 + 537 WP_000429161.1 DNA-binding transcriptional regulator SutR -
MW397_RS11195 (2343052) 2343052..2345013 + 1962 WP_001309488.1 23S rRNA 5-hydroxycytidine C2501 synthase -
MW397_RS11200 (2345105) 2345105..2345335 - 231 WP_000494244.1 YncJ family protein -
MW397_RS11205 (2345557) 2345557..2345733 + 177 WP_064772903.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
MW397_RS11210 (2345779) 2345779..2346195 + 417 WP_076611057.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
MW397_RS11215 (2346274) 2346274..2347680 + 1407 WP_000760613.1 PLP-dependent aminotransferase family protein -
MW397_RS11220 (2347925) 2347925..2349070 + 1146 WP_000047447.1 ABC transporter substrate-binding protein -
MW397_RS11225 (2349088) 2349088..2350101 + 1014 WP_000220413.1 ABC transporter ATP-binding protein -
MW397_RS11230 (2350102) 2350102..2351043 + 942 WP_001251335.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6671.71 Da        Isoelectric Point: 10.9223

>T242302 WP_064772903.1 NZ_CP095529:2345557-2345733 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPCHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T242302 NZ_OW052302:c3882424-3882047 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15251.65 Da        Isoelectric Point: 4.5908

>AT242302 WP_076611057.1 NZ_CP095529:2345779-2346195 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT242302 NZ_OW052302:c3882678-3882421 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References