Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 589127..589649 Replicon chromosome
Accession NZ_CP095529
Organism Escherichia coli strain GN06156

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag MW397_RS02775 Protein ID WP_001105433.1
Coordinates 589359..589649 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8WJ36
Locus tag MW397_RS02770 Protein ID WP_000212718.1
Coordinates 589127..589369 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW397_RS02750 (585040) 585040..586413 + 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
MW397_RS02755 (586496) 586496..587047 - 552 WP_000166270.1 ribosome biogenesis factor YjgA -
MW397_RS02760 (587141) 587141..588493 + 1353 WP_001162171.1 metalloprotease PmbA -
MW397_RS02765 (588549) 588549..588935 + 387 WP_001232253.1 cytochrome b562 -
MW397_RS02770 (589127) 589127..589369 + 243 WP_000212718.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MW397_RS02775 (589359) 589359..589649 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MW397_RS02780 (589650) 589650..590114 - 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MW397_RS02785 (590294) 590294..592432 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
MW397_RS02790 (592826) 592826..594481 - 1656 WP_001376680.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-66)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T242287 WP_001105433.1 NZ_CP095529:589359-589649 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T242287 NZ_OW052302:c2921369-2920959 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9174.63 Da        Isoelectric Point: 5.1369

>AT242287 WP_000212718.1 NZ_CP095529:589127-589369 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLAYPQEAIKVRLDEL

Download         Length: 243 bp

>AT242287 NZ_OW052302:c2921644-2921366 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WJ36

References