Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4948749..4949550 | Replicon | chromosome |
| Accession | NZ_CP095526 | ||
| Organism | Escherichia coli strain GN05505 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | U9ZA48 |
| Locus tag | MW395_RS24915 | Protein ID | WP_001513431.1 |
| Coordinates | 4948749..4949126 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | U9YYT7 |
| Locus tag | MW395_RS24920 | Protein ID | WP_001513429.1 |
| Coordinates | 4949173..4949550 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MW395_RS24890 (4944881) | 4944881..4945864 | - | 984 | WP_001329577.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
| MW395_RS24895 (4946674) | 4946674..4946805 | - | 132 | Protein_4712 | IS110 family transposase | - |
| MW395_RS24900 (4947187) | 4947187..4948029 | - | 843 | WP_001513432.1 | DUF4942 domain-containing protein | - |
| MW395_RS24905 (4948114) | 4948114..4948311 | - | 198 | WP_001374283.1 | DUF957 domain-containing protein | - |
| MW395_RS24910 (4948323) | 4948323..4948698 | - | 376 | Protein_4715 | DUF5983 family protein | - |
| MW395_RS24915 (4948749) | 4948749..4949126 | - | 378 | WP_001513431.1 | TA system toxin CbtA family protein | Toxin |
| MW395_RS24920 (4949173) | 4949173..4949550 | - | 378 | WP_001513429.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MW395_RS24925 (4949713) | 4949713..4949934 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| MW395_RS24930 (4950003) | 4950003..4950479 | - | 477 | WP_001186726.1 | RadC family protein | - |
| MW395_RS24935 (4950495) | 4950495..4950980 | - | 486 | WP_001513428.1 | antirestriction protein | - |
| MW395_RS24940 (4951035) | 4951035..4951853 | - | 819 | WP_001513427.1 | DUF932 domain-containing protein | - |
| MW395_RS24945 (4952032) | 4952032..4952121 | - | 90 | WP_112031555.1 | DUF905 family protein | - |
| MW395_RS24950 (4952264) | 4952264..4952719 | - | 456 | WP_000581502.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13941.80 Da Isoelectric Point: 7.3225
>T242275 WP_001513431.1 NZ_CP095526:c4949126-4948749 [Escherichia coli]
MNTLPDTHVREASGCPSPITIRQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
MNTLPDTHVREASGCPSPITIRQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
Download Length: 378 bp
>T242275 NZ_OW052302:c1614080-1613685 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13688.48 Da Isoelectric Point: 5.9505
>AT242275 WP_001513429.1 NZ_CP095526:c4949550-4949173 [Escherichia coli]
VSDTLPGTTPPDDNHDRPWWGLPCTVTSCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
VSDTLPGTTPPDDNHDRPWWGLPCTVTSCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
Download Length: 378 bp
>AT242275 NZ_OW052302:c1614334-1614080 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|