Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 253873..254510 Replicon chromosome
Accession NC_013169
Organism Kytococcus sedentarius DSM 20547

Toxin (Protein)


Gene name vapC Uniprot ID C7NJK8
Locus tag KSED_RS01230 Protein ID WP_012801756.1
Coordinates 254118..254510 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KSED_RS14810 Protein ID WP_041290823.1
Coordinates 253873..254121 (+) Length 83 a.a.

Genomic Context

KSED_RS01215KSED_RS14810KSED_RS01230KSED_RS13985KSED_RS01205KSED_RS01210KSED_RS01220KSED_RS01235KSED_RS01240KSED_RS01245KSED_RS13980KSED_RS13285KSED_RS14425KSED_RS13990
Location: 251642..252964 (1323 bp)
Type: Others
Protein ID: WP_049758591.1
Location: 253873..254121 (249 bp)
Type: Antitoxin
Protein ID: WP_041290823.1
Location: 254118..254510 (393 bp)
Type: Toxin
Protein ID: WP_012801756.1
Location: 258071..258466 (396 bp)
Type: Others
Protein ID: Protein_251
Location: 249636..250880 (1245 bp)
Type: Others
Protein ID: WP_012801751.1
Location: 250877..251191 (315 bp)
Type: Others
Protein ID: WP_169307763.1
Location: 252999..253811 (813 bp)
Type: Others
Protein ID: WP_012801754.1
Location: 254515..255285 (771 bp)
Type: Others
Protein ID: WP_012801757.1
Location: 255404..256063 (660 bp)
Type: Others
Protein ID: WP_012801758.1
Location: 256113..256454 (342 bp)
Type: Others
Protein ID: WP_012801759.1
Location: 256490..257206 (717 bp)
Type: Others
Protein ID: WP_081439726.1
Location: 257148..257810 (663 bp)
Type: Others
Protein ID: WP_012801761.1
Location: 257854..257976 (123 bp)
Type: Others
Protein ID: WP_115306804.1
Location: 258500..258910 (411 bp)
Type: Others
Protein ID: Protein_252
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KSED_RS01205249636..250880-1245WP_012801751.1cupin-like domain-containing protein-
KSED_RS01210250877..251191-315WP_169307763.1hypothetical protein-
KSED_RS01215251642..252964+1323WP_049758591.1replicative DNA helicase-
KSED_RS01220252999..253811-813WP_012801754.1fused MFS/spermidine synthase-
KSED_RS14810253873..254121+249WP_041290823.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
KSED_RS01230254118..254510+393WP_012801756.1type II toxin-antitoxin system VapC family toxinToxin
KSED_RS01235254515..255285-771WP_012801757.1DUF1524 domain-containing protein-
KSED_RS01240255404..256063-660WP_012801758.1maleylpyruvate isomerase family mycothiol-dependent enzyme-
KSED_RS01245256113..256454-342WP_012801759.1DUF2200 domain-containing protein-
KSED_RS13980256490..257206-717WP_081439726.1HNH endonuclease-
KSED_RS13285257148..257810-663WP_012801761.1FMN-binding protein-
KSED_RS14425257854..257976-123WP_115306804.1Ltp family lipoprotein-
KSED_RS13985258071..258466+396Protein_251transposase family protein-
KSED_RS13990258500..258910-411Protein_252Gfo/Idh/MocA family oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Antitoxin VapB-like

(1-81)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13744.49 Da        Isoelectric Point: 4.3094

>T24227 WP_012801756.1 NC_013169:254118-254510 [Kytococcus sedentarius DSM 20547]
VIVDSSALVAILLAEPERQALLEAIQQAPEAAMTAASYLEVGMVVDGRGNPVLSRQYDALLEALGIEVVDTTAEQARVAR
AAHRDFGRGSGHPARLNFGDCLSYAAAVQDGVPLLFTGDDFIHTDVTPAR

Download         Length: 393 bp

>T24227 NC_013169:254118-254510 [Kytococcus sedentarius DSM 20547]
GTGATCGTCGACTCCTCGGCCCTCGTGGCCATCCTGTTGGCAGAGCCGGAGCGCCAGGCCCTCCTCGAGGCCATCCAGCA
GGCCCCGGAGGCCGCGATGACCGCGGCCTCCTACCTCGAGGTGGGCATGGTGGTGGACGGGCGGGGAAACCCGGTCCTCT
CTCGCCAGTACGACGCCCTGTTGGAGGCCCTCGGTATCGAGGTGGTGGACACCACGGCCGAGCAGGCCCGTGTCGCCCGG
GCGGCGCACCGGGACTTCGGCCGGGGGAGTGGGCACCCGGCGCGCCTGAACTTCGGGGACTGCCTCAGCTACGCCGCCGC
CGTCCAGGATGGGGTCCCCTTGTTGTTCACGGGTGACGACTTCATCCACACGGACGTCACGCCTGCCCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9004.15 Da        Isoelectric Point: 4.6158

>AT24227 WP_041290823.1 NC_013169:253873-254121 [Kytococcus sedentarius DSM 20547]
MALTIKNDRVCDLAREAAQRSGQSQVSVIEQALERYLADHAEPVGRRVDEVLARIDASLAPGDAAAMRVELDRLYDERGL
PA

Download         Length: 249 bp

>AT24227 NC_013169:253873-254121 [Kytococcus sedentarius DSM 20547]
ATGGCACTCACGATCAAGAACGACAGGGTGTGCGACCTGGCCCGCGAGGCGGCGCAGCGCTCGGGACAGTCCCAGGTGTC
CGTCATCGAGCAGGCGTTGGAGCGATACCTGGCCGACCATGCCGAGCCCGTGGGGCGGCGCGTGGACGAGGTGCTCGCCC
GCATCGACGCCAGCCTTGCCCCGGGGGATGCTGCCGCGATGCGCGTCGAGCTCGATCGCCTCTACGACGAACGGGGGCTC
CCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBC7NJK8

Antitoxin

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Source
ID
Structure
No matching records found

References