242184

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3258052..3258706 Replicon chromosome
Accession NZ_CP095518
Organism Escherichia coli strain GN02350

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag MW405_RS15575 Protein ID WP_000244781.1
Coordinates 3258299..3258706 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag MW405_RS15570 Protein ID WP_000354046.1
Coordinates 3258052..3258318 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW405_RS15550 (3254140) 3254140..3255573 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
MW405_RS15555 (3255618) 3255618..3255929 + 312 WP_001182948.1 N(4)-acetylcytidine aminohydrolase -
MW405_RS15560 (3256093) 3256093..3256752 + 660 WP_000250274.1 hemolysin III family protein -
MW405_RS15565 (3256829) 3256829..3257809 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
MW405_RS15570 (3258052) 3258052..3258318 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
MW405_RS15575 (3258299) 3258299..3258706 + 408 WP_000244781.1 protein YgfX Toxin
MW405_RS15580 (3258746) 3258746..3259267 - 522 WP_001055874.1 flavodoxin FldB -
MW405_RS15585 (3259379) 3259379..3260275 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
MW405_RS15590 (3260300) 3260300..3261010 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MW405_RS15595 (3261016) 3261016..3262749 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T242184 WP_000244781.1 NZ_CP095518:3258299-3258706 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T242184 NZ_OW052188:3686995-3687291 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT242184 WP_000354046.1 NZ_CP095518:3258052-3258318 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT242184 NZ_OW052188:3686747-3686998 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References