Detailed information of TA system TA242183

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3167290..3168124
• Replicon: chromosome
• Accession: NZ_CP095518
• Organism: Escherichia coli strain GN02350

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A2T3TJB4
• Locus tag: MW405_RS15065
• Protein ID: WP_000854811.1
• Coordinates: 3167290..3167667 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A2T3TJJ3
• Locus tag: MW405_RS15070
• Protein ID: WP_001285590.1
• Coordinates: 3167756..3168124 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW405_RS15045 (3165088)	3165088..3166308	+	1221	WP_000794251.1	capsular biosynthesis protein	-
MW405_RS15050 (3166334)	3166334..3166564	-	231	Protein_2934	hypothetical protein	-
MW405_RS15055 (3166670)	3166670..3166846	-	177	WP_000839288.1	DUF957 domain-containing protein	-
MW405_RS15060 (3166863)	3166863..3167293	-	431	Protein_2936	DUF5983 family protein	-
MW405_RS15065 (3167290)	3167290..3167667	-	378	WP_000854811.1	type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA	Toxin
MW405_RS15070 (3167756)	3167756..3168124	-	369	WP_001285590.1	type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA	Antitoxin
MW405_RS15075 (3168198)	3168198..3168419	-	222	WP_000692300.1	DUF987 domain-containing protein	-
MW405_RS15080 (3168488)	3168488..3168964	-	477	WP_001536299.1	RadC family protein	-
MW405_RS15085 (3168980)	3168980..3169465	-	486	WP_000214310.1	antirestriction protein	-
MW405_RS15090 (3169557)	3169557..3170375	-	819	WP_001234593.1	DUF932 domain-containing protein	-
MW405_RS15095 (3170493)	3170493..3170664	-	172	Protein_2943	DUF905 family protein	-
MW405_RS15100 (3170765)	3170765..3171220	-	456	WP_000581502.1	IrmA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14041.14 Da
• Isoelectric Point: 7.8839

>T242183 WP_000854811.1 NZ_CP095518:c3167667-3167290 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Nucleotide

• Length: 378 bp

>T242183 NZ_OW052188:3660644-3661063 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13608.50 Da
• Isoelectric Point: 6.6242

>AT242183 WP_001285590.1 NZ_CP095518:c3168124-3167756 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT242183 NZ_OW052188:3660375-3660635 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Structures

Toxin

• AlphaFold DB: A0A2T3TJB4

Antitoxin

• AlphaFold DB: A0A2T3TJJ3