Detailed information of TA system TA024218

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 1409195..1409769
• Replicon: chromosome
• Accession: NC_013037
• Organism: Dyadobacter fermentans DSM 18053

Toxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: DFER_RS05845
• Protein ID: WP_015810688.1
• Coordinates: 1409195..1409515 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: mazF
• Uniprot ID: C6W575
• Locus tag: DFER_RS05850
• Protein ID: WP_015810689.1
• Coordinates: 1409509..1409769 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DFER_RS05825	1404732..1406126	-	1395	WP_015810684.1	aspartate aminotransferase family protein	-
DFER_RS05830	1406258..1406728	-	471	WP_015810685.1	DUF1572 family protein	-
DFER_RS05835	1406721..1407650	-	930	WP_015810686.1	EamA family transporter	-
DFER_RS05840	1407753..1409192	+	1440	WP_015810687.1	PLP-dependent aminotransferase family protein	-
DFER_RS05845	1409195..1409515	-	321	WP_015810688.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
DFER_RS05850	1409509..1409769	-	261	WP_015810689.1	MazE family transcriptional regulator	Antitoxin
DFER_RS05855	1409997..1412012	+	2016	WP_015810690.1	cadmium-translocating P-type ATPase	-
DFER_RS05860	1412091..1412657	+	567	WP_015810691.1	pyridoxamine 5'-phosphate oxidase family protein	-
DFER_RS05865	1412819..1413097	-	279	WP_015810692.1	hypothetical protein	-
DFER_RS05870	1413222..1413602	+	381	WP_015810693.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12009.20 Da
• Isoelectric Point: 9.9560

>T24218 WP_015810688.1 NC_013037:c1409515-1409195 [Dyadobacter fermentans DSM 18053]
MVVKRFEIYFVSLNPTLGSEIRKTRPCLIISPNDLNDHLNTVIVAPLTTTLPKYPTRINCHVDGKDCQIALDQLRTIDKV
RLHKKLGKIDETTAQQVLAVLKKLFA

Nucleotide

• Length: 321 bp

>T24218 NC_013037:c1409515-1409195 [Dyadobacter fermentans DSM 18053]
ATGGTAGTAAAGCGCTTCGAAATCTACTTCGTGTCGCTCAATCCGACTTTGGGCAGCGAAATTAGGAAGACAAGACCCTG
CCTCATTATATCTCCCAATGACCTGAACGACCACCTGAACACGGTGATCGTAGCACCGCTGACCACGACCTTGCCCAAAT
ATCCGACGCGGATCAATTGCCACGTCGATGGAAAGGACTGCCAGATCGCCCTGGATCAACTTCGAACAATCGATAAGGTG
CGTCTCCACAAAAAATTGGGTAAAATCGACGAGACGACAGCCCAACAAGTACTAGCTGTTTTGAAGAAGCTATTTGCTTG
A

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9752.86 Da
• Isoelectric Point: 3.9951

>AT24218 WP_015810689.1 NC_013037:c1409769-1409509 [Dyadobacter fermentans DSM 18053]
MLTKIRRIGNSQGILLSKAMLDQVDIEEYVNVEVKGNAIMIFPASTNPREGWAEQFRLANENEASAEDQNAMGDLFNAFD
DSEWTW

Nucleotide

• Length: 261 bp

>AT24218 NC_013037:c1409769-1409509 [Dyadobacter fermentans DSM 18053]
ATGCTGACTAAAATCCGCCGGATCGGAAATTCCCAGGGAATTTTGCTTTCCAAAGCGATGCTGGATCAGGTTGATATAGA
GGAATATGTCAATGTGGAGGTAAAAGGCAACGCGATCATGATCTTTCCCGCAAGCACCAATCCACGCGAAGGATGGGCTG
AGCAGTTTCGCCTGGCAAACGAAAACGAGGCTTCTGCGGAAGACCAGAACGCAATGGGCGACTTGTTCAATGCCTTCGAT
GATTCGGAATGGACATGGTAG

Structures

Antitoxin

• AlphaFold DB: C6W575