Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4241251..4242085 Replicon chromosome
Accession NZ_CP095514
Organism Escherichia coli strain GN02323

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VDB0
Locus tag MW403_RS20215 Protein ID WP_000854688.1
Coordinates 4241708..4242085 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H2VAY1
Locus tag MW403_RS20210 Protein ID WP_001285596.1
Coordinates 4241251..4241631 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW403_RS20175 (4237536) 4237536..4237991 + 456 WP_000581502.1 IrmA family protein -
MW403_RS20180 (4238070) 4238070..4238303 + 234 WP_001119727.1 DUF905 family protein -
MW403_RS20185 (4238404) 4238404..4239222 + 819 WP_001234616.1 DUF932 domain-containing protein -
MW403_RS20190 (4239277) 4239277..4239762 + 486 WP_000849564.1 antirestriction protein -
MW403_RS20195 (4239778) 4239778..4240254 + 477 WP_001186726.1 RadC family protein -
MW403_RS20200 (4240317) 4240317..4240538 + 222 WP_000692329.1 DUF987 domain-containing protein -
MW403_RS20205 (4240557) 4240557..4241201 + 645 WP_000094917.1 hypothetical protein -
MW403_RS20210 (4241251) 4241251..4241631 + 381 WP_001285596.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MW403_RS20215 (4241708) 4241708..4242085 + 378 WP_000854688.1 TA system toxin CbtA family protein Toxin
MW403_RS20220 (4242082) 4242082..4242570 + 489 WP_000761701.1 DUF5983 family protein -
MW403_RS20225 (4242587) 4242587..4242784 + 198 WP_000839260.1 DUF957 domain-containing protein -
MW403_RS20230 (4242998) 4242998..4244017 + 1020 WP_000875213.1 IS110 family transposase -
MW403_RS20235 (4244301) 4244301..4245146 + 846 WP_001280441.1 DUF4942 domain-containing protein -
MW403_RS20240 (4245215) 4245215..4245610 + 396 WP_000208383.1 DUF6088 family protein -
MW403_RS20245 (4245603) 4245603..4246537 + 935 Protein_3949 nucleotidyl transferase AbiEii/AbiGii toxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / kpsT / kpsM / gspM 4241251..4266844 25593
- flank IS/Tn - - 4242998..4244017 1019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14014.01 Da        Isoelectric Point: 8.5221

>T242158 WP_000854688.1 NZ_CP095514:4241708-4242085 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T242158 NZ_OW052188:c1405467-1405066 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13897.70 Da        Isoelectric Point: 4.7959

>AT242158 WP_001285596.1 NZ_CP095514:4241251-4241631 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT242158 NZ_OW052188:c1405699-1405460 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VDB0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2VAY1

References